Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
PhD: warkar da rauni a kowane nau'in EB (2024)
Ƙirƙirar sabon EB gwani ta hanyar horarwa a cikin yankan-baki, EB-mayar da hankali dabarun kimiyya ya kafa dandamali don bincike na EB na gaba kuma yana ƙarfafa haɗin kai tsaye tsakanin sabis na asibiti da kayan aikin bincike.
Wannan tallafin shine don tallafa wa Dr Ajoy Bardhan a matsayin sabon masani a fannin bincike na EB a Jami'ar Birmingham, UK, inda Farfesa Adrian Heagerty da sauran manyan masana EB za su kula da shi. Yana da mahimmanci a horar da sababbin ƙwararrun EB domin muhimman ayyukan bincike, waɗanda suka haɗa da marasa lafiya da kimiyyar dakin gwaje-gwaje, su ci gaba da haɓaka. Ayyukan Dr Bardhan za su bincikar warkar da rauni a kowane nau'in EB da kuma gano abubuwan da za a iya kaiwa ga hanyoyin kwantar da hankali don rage tabo da haɗarin ciwon daji a cikin DEB.
Game da kudaden mu
| Jagoran Bincike | Dr Ajoy Bardhan / Farfesa Adrian Heagerty |
| Institution | Jami'ar Birmingham, Birtaniya |
| Nau'in EB | Duk nau'ikan EB |
| Hanyar haƙuri | Babu |
| Adadin kuɗi | £125,263.24 |
| Tsawon aikin | 4 shekaru |
| Fara kwanan wata | Satumba 2019 |
| DEBRA ID na ciki | Heagerty_Bardhan1 |
Bayanan aikin
Wannan aikin ya tattara swabs na fata, blister ruwa da jini daga mutanen da ke da nau'ikan EB daban-daban, da mutanen da ba tare da EB ba don kwatantawa. Masu binciken sun kwatanta ƙwayoyin cuta da sauran ƙwayoyin cuta da ke rayuwa akan fata, sunadaran da ke cikin ruwa mai blister, da fararen ƙwayoyin jini waɗanda ke cikin tsarin garkuwar jiki.
Sakamakon ya nuna cewa fatar EB da ta ji rauni tana da ƙwayoyin cuta masu iya lalata da ƙarancin ƙwayoyin cuta waɗanda za su iya zama masu fa'ida. Masu bincike sun kuma ga shaidar ƙwayoyin rigakafi suna yin halayen da za su iya sa alamun EB su yi muni, da canje-canje a cikin sunadaran da ke fitowa daga waɗannan kwayoyin halitta zuwa ruwa mai laushi.
Waɗannan sakamakon sun nuna cewa ƙarfafa haɓakar ƙwayoyin cuta masu amfani na fata zai iya rage ƙwayoyin cuta waɗanda ke rage saurin warkar da rauni. Hakanan magungunan da ke akwai waɗanda ke canza yanayin ƙwayoyin rigakafi za a iya sake yin su don rage alamun EB kamar itching.
An buga sakamakon wannan aikin a cikin mujallun kimiyya:
Dokta Bardhan ya haɗu tare da manyan masana kimiyya a fannin ilimin kwayoyin halitta, bincike na microbiome, kumburi da proteomics don samar da sababbin hanyoyin da za a binciko EB a wurare daban-daban ciki har da nazarin locomotion da kuma maganin cututtuka.
Dr Bardhan ya shiga cikin namu aikin microbiome inda sakamakon farko mai ban sha'awa ya nuna cewa nau'ikan EB daban-daban suna haifar da ƙwayoyin cuta daban-daban da ke rayuwa akan fata waɗanda ke canzawa daban lokacin da raunuka suka fara warkewa. Nazarin ya kuma ba da shaida na martanin rigakafi wanda zai iya haifar da lalacewa maimakon warkarwa a wasu nau'ikan EB.
Wannan tallafin ya kuma ba da gudummawa ga ayyuka da yawa na juyawa bayan kafa sabuwar ƙungiyar bincike ta EB a Birmingham, duk tare da manufar ƙoƙarin ƙoƙarin fahimtar EB da haɓaka sabbin zaɓuɓɓukan jiyya don taimakawa inganta ingancin rayuwa ga waɗanda abin ya shafa.
Dr Bardhan ya buga a labarin sake dubawa EB a cikin 2020, a jagora don gano cututtukan fata na kwayoyin halitta ga likitoci a 2021 a Rahoton akan sabon sanadin kwayoyin halitta na EBS a cikin 2022.
An gabatar da aikinsa a cikin 2021 da 2022:
Mai kyau, mara kyau da mummuna: kumburi a cikin raunuka na epidermolysis bullosa - 2021
Masu tasiri a cikin epidermolysis bullosa: microbiome na cutaneous - 2022
Cicatricial junctional epidermolysis bullosa: subtype da aka manta - 2022
Dr Ajoy Bardhan BSc, MBBS, MRCP (UK) (Dermatology)
Dr Bardhan malami ne na Clinical a Jami'ar Birmingham kuma mai ba da shawara ga likitan fata a Asibitocin Jami'ar Birmingham NHS Trust. Bayan karatun digiri na farko a Kwalejin Imperial ta London da kuma horar da ƙwararrun ƙwararru a Cambridge, ya ƙaura zuwa Birmingham don neman horo na ƙwararrun a fannin ilimin fata. Matsayinsa na farko ya kasance a asibitin Solihull, inda ya dawo don yin haɗin gwiwa a EB a ƙarƙashin kulawar sabis na musamman na rabin ƙasa wanda Farfesa Heagerty ke jagoranta, wanda aka haɓaka ta horon dakin gwaje-gwaje a DGEM, a ƙarƙashin Farfesa McLean. Ƙarin ƙwarewa a cikin EB ya zo a matsayin mai rejista a Asibitin Yara na Birmingham. Ya haɗu da aikin asibiti tare da bincike na kimiyya na asali wanda ke binciko bangarori da yawa na warkar da rauni a cikin EB, yana amfana daga wurare masu kyau, masu haɗin gwiwa, da kulawa daga Farfesa Chapple da Heagerty.
Farfesa Adrian HM Heagerty BSc (Hons), MBBS, MRCP, MD, FRCP
An nada shi a matsayin Mashawarcin Likitan fata a Asibitin Skin Birmingham a cikin 1995, damar ta taso a cikin 1998 don fara sabon sashin ilimin cututtukan fata a Asibitin Solihull, wani bangare na Asibitin Birmingham Heartlands kuma yanzu Asibitocin Jami'a Birmingham NHS Foundation Trust. Farfesa Heagerty yana da alaƙa da ƙungiyar bincike a cikin Epidermolysis Bullosa da Pachyonychia Congenita. A cikin aikinsa na babban magatakarda, ya iya gano iyalai tare da EB Simplex, (EBS) wanda ya haifar da ƙaddarar rashin daidaituwa a cikin EBS. Haɗe tare da aiki a cikin Junctional da Dystrophic nau'ikan EB, kuma daga ƙarshe a matsayin jagora ga NHS Ingila rabin hidimar manya na ƙasa don irin waɗannan marasa lafiya, Farfesa Heagerty ya sami damar yin aiki tare da Farfesa McLean, a Jami'ar Dundee, bincika sabbin fasahohi don hana bayyanar kwayar halitta, ta amfani da samfurin EB azaman misali. An nada Farfesa Heagerty a matsayin Farfesa na Daraja a Jami'ar Birmingham, tare da zama a Cibiyar Kumburi da tsufa, yana aiki tare da Farfesa Chris Buckley, Farfesa Kennedy na Rheumatology, don gano ƙaddamarwar Psoriasis da Psoriatic Arthropathy, tare da Farfesa Janet Lord da abokan aikinta suna nazarin abubuwan da ke haifar da kumburi a cikin Dyscaring Einflammation.
"Yayin da aka ci gaba da bincike mai yawa a cikin maganin kwayoyin halitta, al'ummar EB sun bayyana a fili warkar da raunuka a matsayin wani yanki na mayar da hankali inda ci gaban bincike na kimiyya na asali zai iya zama da sauri da kuma fassara shi cikin sauri zuwa inganta ingancin rayuwa ga marasa lafiya, ta hanyar raguwa. kumburi, scarring da fibrosis. Mun yi sa'a a Birmingham don yanzu muna da wurare da yawa da aka sadaukar don bincike da inganta waɗannan matakai, da kuma kafa haɗin gwiwa tsakanin masu bincike na duniya, asibitin EB da kuma sauran jama'a na EB sun fara ba da 'ya'ya kuma da fatan za su kawo gaskiya. fa'ida ga majinyatan mu nan gaba kadan."
– Dr Ajoy Bardhan
Taken Bayar: DEBRA Clinical Fellow
Haɓaka sabon matsayi na Ilimin Dermatology a Jami'ar Birmingham zai kafa mataki don bunkasa shirye-shiryen bincike na sabon labari tare da fa'idodin fassarar da ake tsammani da haɓaka tallafin asibiti ga marasa lafiya tare da EB a wannan cibiyar, musamman yin amfani da kayan aiki na yankewa a cikin bincike na kumburi da raguwa da rigakafin tabo, tabbatar da bayyananne da ci gaba da mayar da hankali ga EB a nan gaba.
Farfesa Adrian Heagerty, Jagoran EB Adult a Asibitin Solihull, tare da Farfesa Iain Chapple, Farfesa na Periodontology da Restorative Dentistry a Jami'ar Birmingham za su kasance masu kula da Dr Ajoy Bardhan yayin da yake gudanar da karatunsa na MD don bincika abubuwa da yawa na warkar da raunuka a EB. Haɗuwa da aikin asibiti da bincike na kimiyya na asali zai ba shi damar yin amfani da ƙwarewa don yin aikin mai da hankali kan haƙuri da aikin ilimi a nan gaba a EB. Dr Bardhan zai shiga cikin ayyuka da yawa tare da Cibiyar Ikklesiyoyin kumburi da tsufa da kuma Cibiyar Kimiyya ta asibiti. Jami'ar Birmingham kwanan nan ta kafa Cibiyar Bincike ta Scar, bincika sabbin hanyoyin kwantar da hankali don rage tabo, tare da Cibiyar Bioengineering ta haɓaka sabbin samfuran bayarwa. Makarantar Wasanni, Motsa jiki da Kimiyyar Gyarawa kuma suna da sha'awar gano abubuwan da za su inganta rayuwa a EB.
Ayyuka a cikin waɗannan cibiyoyin za su ba Dr Bardhan cikakken bayani a cikin binciken EB na yanzu. Hakanan Farfesa Logan, Metcalfe da Grover za su kula da shi a cikin Cibiyar Bioengineering a Jami'ar Birmingham tare da kulawa daga Dr Lisa Hill, wanda zai goyi bayan Dr Bardhan wajen nazarin tabo, warkar da raunuka da ciwon daji ta amfani da samfurin a cikin dakin gwaje-gwaje, da kuma Drs Melissa Grant, Sarah Kuehne da Josefine Hirschfield a cikin binciken interplay na microbial-immune a cikin raunukan EB.
DEBRA ta riga ta ba da gudummawar wani aikin tare da Farfesa Chapple (Halayen microbiome na fata da bincike na aikin neutrophil a cikin Epidermolysis Bullosa marasa lafiya) kuma Dr Bardhan zai cika aikin nazarin kwayoyin halitta na samfurori na nama a matsayin wani ɓangare na wannan aikin, don kara nuna alamun kumburi.
Dr Bardhan kuma za a yi amfani da shi ta Cibiyar Kimiyyar Kiwon Lafiyar Jama'a a matsayin Babban Malami na Clinical/Mai ba da shawara ga likitan fata a Sashen Kula da cututtukan fata a Asibitin Solihull, wanda ke gudanar da ilimin cututtukan fata na gabaɗaya da asibitocin EB da NHS ke bayarwa.
Babban nauyin EB shine saboda raunuka masu tsayi da maimaitawa waɗanda suke jinkirin warkarwa, a hadarin kamuwa da cuta, suna hade da ciwo da ƙaiƙayi, kuma suna buƙatar suturar lokaci mai tsanani. Warkar da rauni a kan lokaci da maido da aikin fata na yau da kullun ya dogara ne akan aikin tsarin rigakafi, wanda ba wai kawai don share ƙwayoyin cuta masu cutarwa (kamar ƙwayoyin cuta, ƙwayoyin cuta da fungi) akan fata ba, amma kuma don cirewa da sake fasalin mataccen nama. Duk da haka, ba duk ƙananan ƙwayoyin cuta a kan fata suna lalacewa ba, kuma 'mai kyau' ƙananan ƙwayoyin cuta na iya zama mahimmanci ga lafiyar fata da kuma tallafawa da ilmantar da tsarin rigakafi. Har yanzu ba a san ainihin nau'in ƙwayoyin cuta a kan fata a cikin nau'ikan nau'ikan EB daban-daban ba, kuma ba a bayyana martanin rigakafi a cikin raunukan EB ba. Dukansu rashin amsawa mara kyau da/ko wuce gona da iri na rigakafi na iya haifar da waraka mara kyau, ko kasancewar wasu 'mummunan' ƙananan ƙwayoyin cuta da yawa kuma basu isa ba. Har ila yau, ba a sani ba ko ƙananan ƙwayoyin da ke kan fata suna yin umurni da amsawar rigakafi, ko kuma akasin haka, amsawar rigakafi ta bayyana abin da ƙananan ƙwayoyin ke zaune a kan fata.
Mun dauki swabs na fata na mutane masu nau'ikan EB daban-daban a wuraren sabbin blister samuwar, kuma a cikin sa'o'i 48, don bincika yadda ƙwayoyin cuta ke ba da canji yayin farkon matakan warkar da rauni. Mun kuma zana ruwan blister daga sabbin blisters, kuma mun ɗauki jini daga marasa lafiya a lokaci guda don nazarin hanyar da ƙwayoyin rigakafi suka amsa ga rauni, da kuma abubuwan gina jiki na ruwan blister (wanda ke nuna aikin sel a wurin rauni). Mun zaɓa don bincika abubuwan da suka faru a farkon lokacin warkar da rauni, saboda wannan zai iya yin tasiri ga abubuwan da suka faru daga baya a cikin tsarin warkar da rauni. Ta hanyar samun haske game da matakai masu lalacewa da wuri, muna fatan za mu iya gano maƙasudi don gyarawa da inganta ayyukan warkar da rauni na gaba.
Sakamako masu ban sha'awa suna ba da shawarar cewa tashar jiragen ruwa na EB ta haɓaka matakan ƙwayoyin cuta masu cutarwa akan fata da wuri a cikin tsarin warkar da rauni, kuma suna canzawa daban yayin amsawar warkarwa ta farko. Hakanan akwai raguwar matakan ƙwayoyin cuta masu yuwuwar kariya. Ba a taɓa nuna wannan a farkon raunukan EB ba. Mun kuma ga shaidar wuce gona da iri na rigakafi wanda zai iya haifar da lalacewar nama maimakon warkarwa musamman nau'ikan EB. Ana buƙatar ƙarin aiki don bincika dalilin da yasa wannan zai iya zama lamarin, da kuma samun damar gano sabbin maƙasudai don jiyya waɗanda zasu iya taimakawa gyara waɗannan sabbin canje-canjen da aka gano don gwadawa da haɓaka warkarwa ga mutane masu EB.
Mahimmanci, wannan tallafin ya kuma ba da gudummawa ga ayyuka da yawa na juyawa bayan kafa sabon rukunin bincike na EB a Jami'ar Birmingham, duk tare da burin ƙoƙarin ƙoƙarin fahimtar EB da haɓaka sabbin zaɓuɓɓukan jiyya don taimakawa haɓaka ingancin rayuwa. ga wadanda abin ya shafa.