Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
Laraba 3 (2017)
Limbal stem-cell far don RDEB
Game da kudaden mu
| Jagoran Bincike | Farfesa Jakub Tolar, Farfesa a fannin ilimin yara |
| Institution | Sashen Likitan Yara, Jami'ar Minnesota, Amurka |
| Nau'in EB | Duk nau'ikan amma mafi musamman JEB |
| Hanyar haƙuri | N / A |
| Adadin kuɗi | An Kammala $250,000 (Asusun Bincike na Sohana ya ba da izini kuma ya biya shi |
Bayanan aikin
Lalacewar corneal a cikin marasa lafiya na RDEB yana haifar da rashin jin daɗi sosai kuma a cikin raguwar inganci da asarar hangen nesa. Ga waɗanda abin ya shafa, wannan ya kasance ɗaya daga cikin mafi ƙarancin matsalolin cutar RDEB. Kamar yadda dashen jini da bargo ba ya gyara sel a cikin ido-barin marasa lafiya har yanzu suna da rauni ga raɗaɗi mai raɗaɗi - muna so mu haɓaka wani madadin magani wanda ke haifar da sel gyare-gyaren kwayoyin don amfani kai tsaye a cikin ido.
RDEB da sauran cututtuka na kwayoyin halitta suna haifar da "typos" (maye gurbi) a cikin DNA a cikin ƙwayoyin mu. An “rubuta DNA” tare da “haruffa” guda huɗu na musamman (kwayoyin halitta) a cikin haɗe-haɗe dabam-dabam da cikin igiyoyi har tsawon biliyan 3.2 na waɗannan haruffa a cikin takamaiman tsari. Canji zuwa kadan kamar ɗaya daga cikin waɗannan haruffa na iya haifar da cututtukan ƙwayoyin cuta kamar RDEB.
Mun yi shirin ɗaukar ƙaramin ƙwayar ƙwayar ƙwayar cuta daga majiyyaci kuma mu yi amfani da wani nau'i na tiyata a kan waɗannan sel don gyara "typos" har abada wanda ke haifar da rashin samar da nau'in VII collagen. Muna da fasaha wanda zai iya yanke DNA a daidai wuri, cire kuskuren, kuma a hankali kuma musamman maye gurbin tsarin haruffa na al'ada.
Tare da gyaran typo na dindindin a cikin waɗannan sel, muna fatan mayar da su ga majiyyaci. Kwayoyin da aka gyara zasu samar da nau'in VII collagen da ya ɓace kuma lalacewar corneal ba za ta ci gaba ba. Mun riga mun sami nasarar yin wannan tiyatar kwayar halitta a dakin gwaje-gwajenmu don gyara kwayoyin fata.
Muna da kyakkyawan fata cewa za mu iya samar da kwayoyin halittar corneal gyare-gyaren da za su iya inganta rayuwar mutanen da ke da RDEB, wanda kawai zaɓin su a yau shine kulawa da tallafi.
Canje-canje a cikin bincike na gaba.
Shekaru 10 na ƙarshe na binciken RDEB sun kasance juyin juya hali. Magunguna kamar maganin kwayoyin halitta da maganin furotin yanzu suna yiwuwa a jiki, kuma gwaji na farko a cikin salon salula (alurar rigakafi na fibroblasts da kwayoyin stromal mesenchymal, jiko na tsarin kwayoyin halitta na kwayoyin halitta, da kuma tsarin tsarin lokaci mai tsawo ta hanyar jini da dashen bargo) suna da kyau. gudana kuma a ƙarƙashin ci gaba akai-akai.
Ƙungiyoyin bincikenmu koyaushe suna jagora, ƙwazo da ƙwazo daga mutane tare da RDEB da iyalansu. A cikin tarihin shekaru ɗari na wannan cuta, sun jimre da cikas da ba za a iya jurewa ba kuma sun ci gaba da jurewa. Da irin wannan bukata, mun san sun dade da jira. Muna ganin aikinmu a matsayin wani ɓangare na ƙoƙarin duniya don warkar da RDEB, ƙoƙarin da ke ganin sabbin nau'ikan nasara kuma zai gina kan abubuwan da aka gano na shekaru 10 da suka gabata.
"Mun san cewa abin da majinyatan EB da iyalai ke so magani ne. Tallafin DEBRA yana taimaka mana don samun ci gaba wanda zai haifar da ingantattun hanyoyin kwantar da hankali da fatan, magani.
Dr Jakub Tolar
Dr Jakub Tolar
Dokta Jakub Tolar shi ne Daraktan Cibiyar Kula da Kwayoyin Halitta kuma Farfesa a Jami'ar Minnesota. Bincikensa ya haifar da amfani da ƙwayar kasusuwa na farko a matsayin farfadowa na dystrophic epidermolysis bullosa (RDEB)> Yanzu yana haɓaka sababbin jiyya ta amfani da sel daga RDEM marasa lafiya da kansu. Yana bincika duka abubuwan da ke faruwa a zahiri, ƙwayoyin da aka gyara da kansu da sel da aka gyara a matsayin tushen furotin don raunin fata da kuma jiyya na gaba ɗaya. Dr Tolar da tawagarsa suna aiki tuƙuru don matsar da waɗannan ra'ayoyin daga dakin gwaje-gwaje zuwa asibiti.