Tolar 2

Fatar da ke da rauni na mutanen da ke da recessive dystrophic epidermolysis bullosa (RDEB) yana faruwa ne ta hanyar kuskuren kwayoyin halitta (maye gurbi) wanda ke yin katsalandan ga samar da furotin na yau da kullun da ake kira collagen VII. A cikin fata ta al'ada, collagen VII yana haifar da zaruruwa waɗanda ke riƙe sassan fata tare. A ka'idar, gyara kuskuren kwayoyin halitta zai haifar da samar da collagen VII da kuma dawo da aikin al'ada a cikin fata.

Wannan rukunin yana haɓaka sabuwar fasaha mai ban mamaki don gyara kurakuran kwayoyin halitta. Wannan fasaha, mai suna TALEN (Transcription Activator-Like Effector Nuclease), yana ba su damar kai hari ga kuskuren kwayar halitta, yanke shi da shigar da daidaitaccen jerin kwayoyin halitta. Wannan yakamata ya zama haɓaka akan yunƙurin da aka yi a baya na maganin ƙwayoyin cuta wanda ya ƙara daidaitattun kwayoyin halitta a bazuwar.

Masu binciken suna amfani da software na kwamfuta mai ƙarfi don gano takamaiman wurare a cikin DNA ta kowane bangare na sashe mara kyau. Daga nan sai su kera kwayoyin halitta don gane wadannan wuraren da manne da su. Wadannan kwayoyin suna kuma dauke da wani sinadari da ke yanke DNA kuma yana kawar da kuskuren kwayoyin halitta. Binciken DNA daga binciken da aka yi a halin yanzu ya nuna sun yi nasara wajen cirewa da maye gurbin sassan da suka dace na DNA a cikin kwayoyin fata na EB.

Wannan rukunin ya ɗauki ƙwayoyin fata daga marasa lafiya na RDEB kuma sun yi amfani da fasaha na zamani don haɓaka su da yawa a cikin dakin gwaje-gwaje. Har ila yau, sun yi amfani da wata fasaha da ke ba wa waɗannan kwayoyin halitta kaddarorin kwayoyin halitta, wanda zai iya haifar da nau'o'in sel daban-daban a ƙarƙashin ingantattun yanayi. Da zarar an inganta tsarin gyaran kwayoyin halitta, sel da aka gyara daga marasa lafiya za a iya girma a cikin dakin gwaje-gwaje zuwa nau'ikan sel daban-daban masu amfani don gyaran fata da kuma dasawa.

Fasahar da aka haɓaka a cikin wannan binciken yana da tasiri mai zurfi ga makomar bincike a cikin RDEB da maganinta.

"Taimako daga DEBRA ya kasance mai mahimmanci wajen ba mu damar ɗaukar sabbin kwatance don neman ingantacciyar magani ga RDEB, misali ta amfani da fasahar gyara kwayoyin halitta"

Dr Jakub Tolar

Dr Jakub Tolar

Dokta Jakub Tolar shi ne Daraktan Cibiyar Kula da Kwayoyin Halitta kuma Farfesa a Jami'ar Minnesota. Bincikensa ya haifar da amfani da farko na dashen kasusuwa a matsayin magani ga recessive dystrophic epidermolysis bullosa (RDEB). Yanzu yana haɓaka sabbin jiyya ta amfani da sel daga marasa lafiyar RDEB da kansu. Yana binciken kwayoyin halitta da aka gyara da kansu da kuma sel da aka gyara a matsayin tushen samar da furotin don raunukan fata da kuma jiyya na gaba ɗaya. Dokta Tolar da tawagarsa suna aiki tuƙuru don motsa waɗannan ra'ayoyin daga dakin gwaje-gwaje zuwa asibiti.