Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
Magungunan tantancewa don kai hari kan kansar RDEB
Sama da magungunan 3000 da aka amince da su za a bincika don gano waɗanda ke kashe ƙwayoyin cutar kansar fata kuma za a iya sake yin su don magance mummunan nau'in kansar fata wanda ke shafar mutane da RDEB akai-akai.
Farfesa Gareth Inman yana aiki a Jami'ar Glasgow, UK, akan ciwon daji na fata a RDEB. A cikin wannan aikin, zai yi amfani da magunguna sama da 3000 da aka amince da su ga ƙwayoyin da aka girma a cikin dakin gwaje-gwajensa don gano waɗanda ke kashe ƙwayoyin cutar kansa ba tare da cutar da ƙwayoyin da ba su da kansa. Wadanda suka wuce gwajin za su kasance ƙarƙashin gwajin ƙarin gwaji don samar da shaida don tallafawa amfani da su a cikin gwajin sake dawo da ƙwayoyi na gaba.
Game da kudaden mu
| Jagoran Bincike | Prof. Gareth Inman |
| Institution | Ciwon daji Research UK Beatson Institute, Jami'ar Glasgow, Scotland, Birtaniya |
| Nau'in EB | RDEB |
| Hanyar haƙuri | Babu wani - ƙwayoyin marasa lafiya suna girma a cikin dakin gwaje-gwaje |
| Adadin kuɗi | £96,891.52 (haɗin gwiwa tare da DEBRA Ireland) |
| Tsawon aikin | 18 watanni |
| Fara kwanan wata | 1F Fabrairu 2023 |
| DEBRA ID na ciki | GR000012 |
Bayanan aikin
Masu bincike sun ba da rahoton cewa suna kan hanyar gano magunguna guda biyu waɗanda za a iya amfani da su cikin sauri da aminci a cikin gwaje-gwajen asibiti don magance ciwon daji na RDEB.
Jagoran Bincike:
Farfesa Gareth Inman shi ne Daraktan Dabarun Bincike a Cibiyar Nazarin Ciwon daji ta CRUK Beatson kuma Farfesa na Siginar Halitta a Cibiyar Nazarin Ciwon daji, Jami'ar Glasgow, Scotland. Babban abin da ya fi so shi ne fahimtar irin rawar da membobin kungiyar Beta (TGFβ) ke takawa wajen bunkasa ciwon daji da ci gaba. Nazarinsa ya mayar da hankali ne akan ciwon daji na fata, kai da wuyansa da kuma pancreas kuma yanzu ya haɗa da waɗannan ciwon daji da ke tasowa a cikin marasa lafiya da ke zaune tare da Recessive Dystrophic Epidermolysis Bullosa.
Co-bincike:
Farfesa Karen Blyth, babban masanin kimiyyar ma'aikata a Cibiyar CRUK Beatson.
Masu haɗin gwiwa:
Farfesa Owen Sansom, Farfesa Crispin Miller, Dr Leo Carlin, Dr Lynn McGarry (duk a Cibiyar CRUK Beatson); Dr Andrew South (Jami'ar Thomas Jefferson, Philadelphia) da Farfesa Irene Leigh (Jami'ar Sarauniya Mary, London, UK).
"Irin sake amfani da magungunan ƙwayoyi da aka riga aka amince da shi don amintaccen amfani a cikin marasa lafiya tare da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun tsari da tsarin tsarawa yana da damar da za a iya amfani da su ga marasa lafiyar EB. Anan za mu gudanar da allon sake dawo da magunguna marasa son zuciya sama da 3,000 da aka amince da FDA… A ƙarshen waɗannan binciken za mu gano kuma mu sha magunguna 2 gabaɗaya ta cikin bututun mu wanda zai ba da kwararan hujjoji ga saurin tura su a gwaji na asibiti. a cikin marasa lafiya na RDEB don maganin cutar kansa mai saurin kisa na wannan mummunar cuta."
– Farfesa Gareth Inman
Taken Ba da Tallafi: Maimaituwar ƙwayoyi don maganin RDEB squamous cell carcinoma.
Recessive Dystrophic Epidermis Bullosa (RDEB) yana faruwa ne ta hanyar maye gurbi a cikin kwayar halittar COL7A1 wanda ke sanya nau'in VII collagen (C7), babban bangaren da ake buƙata don daidaiton tsarin haɗin epidermal-junction a cikin fata. Marasa lafiya na RDEB suna fama da matsanancin rauni na fata, kumburin fata mai dagewa da rauni kuma suna da babban haɗari na haɓaka da wuri-farko, m kuma a ƙarshe na cutar sankara na squamous cell carcinoma (cSCC). RDEB cSCC yana tasowa a cikin yanayi mai izini na kumburi na yau da kullum, warkar da raunuka da fibrosis wanda aka sauƙaƙe ta wani ɓangare ta hanyar ciwon daji da ke hade da fibroblasts (CAFs). A halin yanzu akwai rashin cikakkiyar fahimta game da pathogenesis na RDEB cSCC kuma babu a halin yanzu da aka amince da maganin jiyya da aka yi niyya.
Anan za mu gudanar da allon sake dawo da magunguna na sama da magunguna 3,000 da aka riga aka amince da su don amfani da marasa lafiya da wasu yanayi na cututtuka. Za mu haɓaka da kuma tsaftace bututun mai tsattsauran mataki-hikima wanda aka ƙera don tantance ingancin magunguna don hana RDEB cSCC ciwan ƙwayar ƙwayar cuta duka a cikin in-vitro da in-vivo; mahimman alamomi na amfani da warkewa. Za mu bayyana mahimmancin CAFs a cikin tumourigenesis da amsawar ƙwayoyi kuma za mu gano magungunan 2 waɗanda ke nuna tasiri ta hanyar bututun mu.
Wannan tsari zai ƙetare tsarin hana cin lokaci da tsada na ci gaban miyagun ƙwayoyi da gwajin aminci kuma zai ba da shaida mai ƙarfi don saurin tura waɗannan magunguna na 2 a cikin marasa lafiya a cikin gwaji na asibiti don RDEB cSCC far.
Recessive Dystrophic Epidermis Bullosa (RDEB) yana faruwa ne ta hanyar maye gurbi a cikin kwayar halittar COL7A1 wanda ke ɓoye nau'in VII collagen (C7), babban ɓangaren ƙulla fibrils waɗanda ake buƙata don daidaiton tsarin haɗin epidermal a cikin fata. Marasa lafiya na RDEB suna fama da matsanancin rauni na fata, kumburin fata mai dagewa da rauni kuma suna da babban haɗari na haɓaka da wuri-farko, m kuma a ƙarshe na cutar sankara na squamous cell carcinoma (cSCC). RDEB cSCC yana tasowa a cikin yanayi mai izini na kumburi na yau da kullum, warkar da raunuka da fibrosis wanda aka sauƙaƙe ta wani ɓangare ta hanyar ciwon daji da ke hade da fibroblasts (CAFs). A halin yanzu akwai rashin cikakkiyar fahimta game da pathogenesis na RDEB cSCC kuma babu a halin yanzu da aka amince da maganin jiyya da aka yi niyya.
Anan muna gudanar da allon sake fasalin magani na sama da magunguna 3,000 da aka riga aka amince da su don amfani da marasa lafiya da wasu yanayi na cuta. Muna haɓakawa da kuma sabunta bututun bututun da aka ƙera don tantance ingancin magunguna don hana RDEB cSCC ƙwayar ƙwayar ƙwayar cuta duka a cikin in-vitro da in-vivo; mahimman alamomi na amfani da warkewa. Za mu bayyana mahimmancin CAFs a cikin tumourigenesis da amsawar ƙwayoyi kuma za mu gano magungunan 2 waɗanda ke nuna tasiri ta hanyar bututun mu. Wannan tsari zai ƙetare tsarin hana cin lokaci da tsada na ci gaban miyagun ƙwayoyi da gwajin aminci kuma zai ba da shaida mai ƙarfi don saurin tura waɗannan magunguna na 2 a cikin marasa lafiya a cikin gwaji na asibiti don RDEB cSCC far.
(Daga rahoton ci gaba na 2024).