Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
PhD: rage tabon ido na DEB/JEB
EB na iya rinjayar cornea wanda ke haifar da ciwo mai tsanani da rashin hangen nesa. Wannan aikin, wanda aka fara ɗaukarsa a matsayin ɗan ƙaramin taimako, yanzu zai ba da gudummawar kuɗi don horar da sabon ƙwararren ido na EB. Za su yi girma sel daga corneas na ɗan adam waɗanda za su iya fuskantar halayen tabo kamar waɗanda suke a idanun mutanen da ke da EB. Ana iya amfani da waɗannan don gwaje-gwajen farko na yuwuwar rigakafin tabo ido don ceton idanun yara masu EB.
Dokta Gink Yang zai kula da wani dalibin PhD a dakin gwaje-gwaje na Farfesa Keith Martin a Jami'ar Melbourne, Ostiraliya, don bunkasa kwayar idon ɗan adam daga corneas da aka ba da gudummawa. Za su yi amfani da fasahar siRNA don rage adadin collagen (don kwaikwayon RDEB) ko laminin (don kwaikwayon JEB) waɗanda ƙwayoyin ido ke samarwa. Mataki na farko na wannan aikin zai kasance don tabbatar da cewa wannan yana aiki kuma sel sun fara nuna hali kamar suna daga majinyacin EB. Sa'an nan, za a iya gwada wani abu mai hana tabo akan waɗannan kwayoyin halitta don ganin ko yana rage EB canje-canje da kuma yadda yake yin haka. Idan wannan ya ba da shaidar cewa maganin warkewa yana da tasiri, za a iya ci gaba zuwa ƙarin gwaji.
Game da kudaden mu
| Jagoran Bincike | Farfesa Keith Martin |
| Institution | Cibiyar Binciken Ido Ostiraliya (CERA), Jami'ar Melbourne, Ostiraliya |
| Nau'in EB | RDEB da JEB |
| Hanyar haƙuri | Babu |
| Adadin kuɗi | £ 15,000 zuwa karatun PhD |
| Tsawon aikin | 3 shekaru |
| Fara kwanan wata | 11 Janairu 2025 |
| DEBRA ID na ciki | GR000016 |
Bayanan aikin
Domin 2026.
Jagoran bincike:
Farfesa Keith Martin Babban Babban Jami'in Bincike ne a Jami'ar Cambridge kuma Shugaban Ilimin Ophthalmology a Jami'ar Melbourne (UoM). Farfesa Martin ya kasance Darakta na Cibiyar Binciken Ido ta Australia (CERA) na tsawon shekaru uku, amma dakin gwaje-gwajensa na Cambridge ya ci gaba da aiki, wanda wani bangare na Fight for Sight ke tallafawa. A matsayin Darakta na CERA, Farfesa Martin yana jagorantar gungun masu bincike daban-daban da ke gudanar da manyan manyan bincike na asali da na asibiti a cikin binciken ido. Farfesa Martin ƙwararren glaucoma ne wanda ke da sha'awar haɓaka sabbin hanyoyin kwantar da hankali don karewa da dawo da hangen nesa a cikin glaucoma.
Masu bincike:
Dr Gink Yang yana da ilimin kimiyya mai karfi a cikin epidermolysis bullosa (EB) da EB-induced squamous cell carcinoma, maganin farfadowa, gyaran raunuka da kwayoyin halitta. Dr Yang ya buga akan EB-induced fata blistering, EB-kindler ciwo, da squamous cell carcinoma. An ba shi kyautar Asusun Innovation na CERA don ingantacciyar hanyar hana tabo ga cornea a cikin 2021 kuma ya sami sakamako mai ban sha'awa na wannan binciken. Yanzu yana fatan tabbatar da ingancin wannan abu don tabo na corneal a cikin recessive da junctional EB. Dr Yang ne zai jagoranci aikin a kowace rana, inda Farfesa Martin ke bin diddigin ci gaba a kowane wata. Farfesa Daniell zai ba da ƙarin tallafin asibiti da kimiyya.
Farfesa Mark Daniell shine Shugaban Bincike na Corneal a CERA / UoM kuma yana jagorantar Sashin Corneal a Asibitin Ido da Kunne na Royal Victorian. Jigogi na bincike na dakin gwaje-gwaje na Farfesa Daniell sun hada da kimiyyar asibiti na corneal, haɓaka kayan aikin tiyata, dystrophy na corneal, keratoconus, da scarring na corneal - sabon jigo wanda Dr Gink Yang ya jagoranta, Ma'aikacin Farko (PhD da aka bayar a watan Agusta 2020) Abokin Bincike a CERA da Daraja. Abokin ciniki a UoM.
"Binciken marasa lafiya na kasa da kasa game da marasa lafiya na EB a cikin 2020 ya ruwaito marasa lafiya suna yin sharhi cewa zaizayar corneal 'yawanci yana rufe rayuwata gaba daya' kuma 'yana daya daga cikin mafi munin batutuwan sakandare da ke hade da EB, idan ba mafi zafi ba.' Aikin da aka tsara na asali ne na bincike; duk da haka, babban makasudin aikin shine samar da wani sabon salo na kawar da tabo ga majinyatan EB da ke fuskantar yashwar corneal da tabo. Binciken da aka gabatar na iya bayyana ƙarin maƙasudin sabon labari don tabo ta EB da ta haifar da tabo. Wannan zai ƙara haɓaka bincike da haɓaka wasu magunguna ga masu cutar EB a nan gaba. ”
- Farfesa Keith Martin
Title Grant: Rage tabo a cikin epidermolysis bullosa tare da wani sabon abu
Taƙaitaccen bayani da buƙatun binciken: Epidermolysis bullosa cuta ce da ba kasafai ake samun gado ba wacce ke haifar da kumburin fata da kuma saman jikin mucosa, gami da ido. Rayuwa tare da wannan cuta kamar rayuwa ne tare da ƙonewar digiri na uku. Masu fama da cutar sun hana motsi kuma sau da yawa dole ne a ɗaure su kowace rana don karewa da magance raunukan su masu raɗaɗi. Ƙayyadaddun maye gurbi a wasu nau'in wannan cuta kuma suna da tasiri mai tsanani akan lafiyar cornea - madaidaicin launi na ido. Ƙwaƙwalwar ƙwayar cuta wani muhimmin ɓangare ne na tsarinmu na gani, kuma duk wani yashewa ko tabo ga cornea na iya haifar da ciwo mai tsanani da kuma rashin hangen nesa. Jiyya na asibiti na yanzu don epidermolysis bullosa ciki har da yin amfani da ruwan tabarau na lamba, lubrication, da maganin rigakafi don rage alamun bayyanar, amma ba a ba da mafita don hana tabo a cikin cornea ba. Tabo na corneal na iya haifar da mummunar tabarbarewa ga hangen nesa, kuma saboda haka ingancin rayuwa, ga waɗanda suka rigaya ke faɗan yaƙe-yaƙe na yau da kullun da ba za a iya misaltuwa ba.
Manufar binciken: Binciken mu yana da nufin haɓaka ɗigon ido na rigakafin tabo ga masu fama da cutar bullosa epidermolysis ta amfani da wani sabon abu.
Hanyar bincike: An nuna alamar sabon abu don taƙaita hanyoyin ƙwayoyin ƙwayoyin cuta da ke da alhakin tabo na corneal da kuma inganta bayyananniyar kuncin a cikin karatunmu na farko. Makasudin aikin shine tabbatar da ingancinsa a cikin nau'ikan epidermolysis bullosa ta amfani da ƙwayoyin corneal na ɗan adam. Kwayoyin corneal na ɗan adam za a keɓe daga kurwan da aka ba da gudummawa kuma a sake tsara su na ɗan lokaci don yin kwaikwayi halaye daga takamaiman nau'ikan epidermolysis bullosa. Daga nan za mu gudanar da wannan al'adar ta al'adar tantanin halitta bayan shigar da fibrosis kuma mu tantance ingancinta ta amfani da biochemistry da microscopy.
Amfanin asibiti: Idan aka yi la’akari da rikitattun illolin kiwon lafiya na epidermolysis bullosa, yana da mahimmanci a tabbatar da cewa magungunan da ke ƙarƙashin haɓakar wannan cuta suna da takamaiman manufa kuma ba za su haifar da illar da ba za a yarda da su ba. Binciken da ya dogara da dakin gwaje-gwajenmu ta amfani da keɓantattun ƙwayoyin jikin mutum da gyare-gyare na musamman na ƙayyadaddun ƙwayoyin cuta don ƙirar ƙananan nau'ikan cuta zai sauƙaƙe ingantaccen ingantaccen sabon magani. Sakamako daga wannan binciken zai bayyana idan abin da ke hana tabo yana da aminci da tasiri a matakin salula. Wannan muhimmin mataki ne zuwa gwaje-gwaje na farko, inda za'a iya ƙara kimanta tasirin tsarin tsarin maganin tabo. Babban makasudin wannan bincike shine samar da ɗigon ido ta amfani da abin da ke hana tabo ga majinyata da ke fama da tabo na corneal na epidermolysis bullosa. Da zarar an haɓaka, za a yi amfani da ɗigon ido ga marasa lafiya duka a matsayin rigakafi da magani don yashwar corneal / tabo. Wannan na iya yuwuwar rage buƙatar yin amfani da dogon lokaci na maganin rigakafi da steroids, don haka rage haɗarin illa masu illa daga waɗannan jiyya da ake da su.
Domin 2026.