Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
Abokin Hulɗa: RDEB samfuran kansar pre-asibiti
Wannan haɗin gwiwa tare da Cibiyar Nazarin Ciwon daji ta Birtaniya Scotland Cibiyar za ta fitar da sababbin samfurori na RDEB ciwon daji da za a iya amfani da su don fahimtar yadda ciwon daji ke faruwa da ci gaba da kuma gwada hanyoyin kwantar da hankali na gaba.
Takaita aikin
Farfesa Gareth Inman yana aiki a CRUK Scotland Institute, UK, akan wannan haɗin gwiwa don ƙirƙirar sabbin nau'ikan ciwon daji na RDEB.
Ba za a iya gwada sabbin jiyya a kan mutane ba har sai an sami kyakkyawar shaida cewa za su kasance lafiya da tasiri.
Samfuran da aka riga aka yi na asibiti wannan haɗin gwiwa ya ba da shawarar ƙirƙirar suna da mahimmanci ga wannan matakin a cikin aiwatar da matsawa zuwa sabbin hanyoyin kwantar da hankali don ciwon daji na RDEB.
Game da kudaden mu
| Jagoran Bincike | Prof. Gareth Inman |
| Institution | Ciwon daji Research UK (CRUK) Cibiyar Scotland (tsohon CRUK Beatson) |
| Nau'in EB | RDEB |
| Hanyar haƙuri | A'a |
| Adadin kuɗi | Haɗin gwiwa daga DEBRA UK da Cibiyar CRUK Scotland |
| Tsawon aikin | 5 shekaru |
| Fara kwanan wata | Afrilu 2024 |
| DEBRA ID na ciki | GR000051 |
Bayanan aikin
Domin 2025.
Jagoran bincike: Farfesa Gareth Inman shi ne Daraktan Dabarun Bincike a Cibiyar Nazarin Ciwon daji ta Burtaniya (CRUK) Cibiyar Scotland. Nazarinsa ya mayar da hankali ne akan ciwon daji na fata na fata, ciki har da marasa lafiya da ke zaune tare da Recessive Dystrophic Epidermolysis Bullosa.
Co-bincike: Farfesa Karen Blyth, Cibiyar CRUK Scotland;
Masu haɗin gwiwa: Farfesa Owen Sansom, Cibiyar CRUK Scotland, Farfesa Crispin Miller, Cibiyar CRUK Scotland, Dr Andrew South, Jami'ar Thomas Jefferson, Philadelphia, Farfesa Irene Leigh, Jami'ar Sarauniya Mary, London, UK da Dr Alexander Nyström, Jami'ar Freiberg, Jamus.
"Mahimmanci za mu samar da samfurori na farko na asibiti waɗanda ke da mahimmanci ga gwajin gwaji na farko na magungunan warkewa kafin a fara gwajin su a cikin yawan marasa lafiya ... bincike."
– Prof Inman
Sunan bayar: Tsarin pre-clinical na RDEB squamous cell carcinoma.
Recessive Dystrophic Epidermis Bullosa (RDEB) yana faruwa ne ta hanyar maye gurbi a cikin kwayar halittar COL7A1 wanda ke sanya nau'in VII collagen (C7), babban bangaren da ake buƙata don daidaiton tsarin haɗin epidermal-junction a cikin fata. Marasa lafiya na RDEB suna fama da matsanancin rauni na fata, kumburin fata mai dagewa da rauni kuma suna da babban haɗari na haɓaka da wuri-farko, m kuma a ƙarshe na cutar sankara na squamous cell carcinoma (cSCC). RDEB cSCC yana tasowa a cikin yanayi mai izini na kumburi na kullum, raunin rauni da fibrosis.
Akwai rashin isasshen fahimtar abubuwan da suka faru na kwayoyin halittar da ke haifar da samuwar ciwace-ciwacen daji da kuma yadda ƙwayoyin tumor ke hulɗa da ƙarancin fata na C7. Saboda haka, babu wasu hanyoyin kwantar da hankali da aka amince da su don maganin wannan cuta mai muni. Wannan gaskiyar da ba za a iya yarda da ita ba ta kasance saboda ƙarancin ƙirar gwaji na RDEB cSCC waɗanda ke sake dawo da ƙwayoyin ƙwayar cuta da aminci da mu'amalar ƙwayoyin ƙwayoyin cuta. Anan za mu cike wannan gibin ta hanyar yunƙurin haɓakawa da kuma siffanta yanayin fasahar kere-kere da sabon salo na RDEB cSCC wanda za'a iya dasa shi daidai da ƙari da ƙwayoyin ƙwayoyin cuta. Za mu ayyana rawar C7 asara a cikin tumorigenesis kuma za mu yi tambayoyi game da yanayin kwayoyin cutar ciwace-ciwacen da kuma samun zurfin fahimta game da pathogenesis na RDEB cSCC. Waɗannan samfuran za su samar da dandamali masu ƙima don fahimtar ci gaban cutar RDEB cSCC da kuma tsarukan ƙarfi masu ƙarfi waɗanda za a gwada magungunan da ke yin niyya kan hanyoyin tuki kafin gwajin asibiti na gaba na gaba.
Marasa lafiya na RDEB akai-akai suna tasowa da wuri-wuri mai saurin kamuwa da cututtukan fata (cSCC). Cikakken fahimtar RDEB cSCC ya kasance mai wuyar gaske kuma babu ingantattun jiyya ko hanyoyin da aka yarda da su. Bugu da ƙari kuma, akwai ƙayyadaddun ƙididdiga na samfurori na farko na asibiti don fahimtar abubuwan da suka faru na halitta wanda ke haifar da ci gaban RDEB cSCC da ci gaba, duk waɗanda a halin yanzu suna fama da rashin lafiyar cSCC, dacewa da amfani da kuma dacewa ga gwajin magunguna na farko. don magungunan da ake buƙata cikin gaggawa don wannan mummunan rikice-rikice na RDEB. Anan za mu haɓaka ingantattun injina na haɓakar ƙwayoyin halitta da sauƙin sassauƙa na RDEB cSCC dangane da abubuwan da suka faru na kwayoyin halitta na wannan ciwon daji. Za mu ba da sabon haske game da pathogenesis na cuta mai yuwuwar gano sabbin maƙasudi don shiga tsakani na warkewa. Za mu ƙayyade mahimmancin mahimmancin asarar maganganun C7 daga ƙwayoyin tumor da keratinocyte na epidermal da dermal fibroblast sassan fata a cikin fata mai mahimmanci don ƙaddarar da ya dace na dabarun maye gurbin C7 na gaba. Mahimmanci za mu ƙirƙira samfuran pre-na asibiti waɗanda ke da mahimmanci don ƙwaƙƙwaran gwajin gwaji na farko na magungunan warkewa kafin gwajin su a cikin yawan majinyata.
Samfuran da za mu haɓaka a nan za su kasance masu dacewa don ba kawai gwaji na hasashen halittu masu tasowa ba har ma don daidaitaccen nazarin rigakafin ƙwayar cuta, nazarin jiyya na miyagun ƙwayoyi da ƙira na jadawalin tsarin jiyya da binciken guba, yana haɓaka yuwuwar aminci da ingantaccen gwaji na asibiti. aiwatar da sabbin dabarun warkewa cikin gaggawa.
Domin 2025.