Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
O'Toole (2015)
Rarraba rawar da aka gyara membrane na ginshiki a cikin ƙirar xenograft na SCC mai cuta
Game da kudaden mu
| Jagoran Bincike | Farfesa Edl Ann O'Toole, Farfesa na Molecular Dermatology, mai ba da shawara mai mahimmanci ga likitan fata. |
| Institution | Cibiyar Binciken Cutaneous, Cibiyar Blizard na Kwayoyin Halitta da Kimiyyar Kwayoyin Halitta Jami'ar Sarauniya Mary ta London |
| Nau'in EB | DEB |
| Hanyar haƙuri | N / A |
| Adadin kuɗi | £173, 877 (01/01/2011 - 01/05/2015) |
Bayanan aikin
Nau'in VII collagen (ColVII) wani kwayoyin halitta ne wanda ke da alhakin riko na sama (epidermis) zuwa ƙananan (dermis) na fata. Marasa lafiya tare da recessive dystrophic epidermolysis bullosa (RDEB) sun rage ko ba su da matakan ColVII saboda kuskure a cikin DNA. A sakamakon haka, marasa lafiya suna da kumburi da tabo na fata da kuma ƙara haɗarin nau'in ciwon daji na fata, squamous cell carcinoma (SCC). Marasa lafiya suna haɓaka SCC a wuraren tabo a farkon shekaru goma na rayuwa, kuma da yawa suna mutuwa a cikin shekaru 5 bayan an cire SCC na farko.
A cikin wannan binciken masu binciken sun bincikar tasirin ragewa / rashin matakan ColVII akan halayen SCC na cuta ta amfani da tsangwama na RNA (RNAi), dabarar da ake amfani da ƙwayoyin SCC a cikin dakin gwaje-gwaje don rasa maganganun ColVII. Sun nuna cewa ƙwayoyin SCC ba tare da ColVII suna da haɓaka ƙaura da yuwuwar mamayewa suna nuna cewa suna da haɓakar haɓakar metastasis, watau yaduwa zuwa wuraren da ke wajen fata.
An kuma ga sauran abubuwan da suka shafi samuwar ciwon daji kamar rashin tsari (wani tsari na ilimin lissafi inda kwayoyin halitta a cikin ƙananan ɓangaren epidermis suka yi tafiya zuwa sama ta hanyar sauye-sauye masu ci gaba kuma yawanci ana cire su a cikin ciwon daji na fata), da ƙananan matakan kwayoyin da aka sani. don "taimakawa" kwayoyin cutar daji don mamayewa. Kwayoyin da aka sani da TGF-beta da alama yana da hannu a cikin ciwon daji na fata a cikin sel tare da asarar ColVII. Suka yi a vivo gwaje-gwaje kuma sun sami damar nuna cewa sel waɗanda ba su bayyana ColVII suna mamayewa da yawa kuma suna bayyana manyan matakan TGF-beta da sauran kwayoyin da suka dace da mamayewar tantanin halitta, suna tabbatar da sakamakon baya.
Sun kuma nuna a cikin dakin gwaje-gwaje da kuma a cikin a vivo samfurori waɗanda asarar ColVII yana ƙaruwa angiogenesis, wani tsari inda sababbin hanyoyin jini ke samuwa daga waɗanda suka rigaya. Angiogenesis yana da muhimmiyar rawa a cikin ci gaban ƙari kamar yadda yake "taimakawa" ƙwayoyin ƙari don rayuwa ta hanyar samar da iskar oxygen da abubuwan gina jiki. An tabbatar da canje-canjen da aka lura a cikin sassan fata daga RDEB SCC marasa lafiya. Kwanan nan, sun sami damar yin allurar ɗan adam recombinant ColVII (wanda aka sani yana kama da ɗan adam na ɗan adam ColVII) da kuma sake dawo da hanyoyin jini yana ƙara tabbatar da rawar ColVII a cikin angiogenesis.
Sun yi nazarin ƙarin abubuwan haɓaka da ke tattare da angiogenesis kuma sun gano Fa'idodin Ci gaban Endothelial na Vascular a matsayin wani muhimmin ƙananan ƙwayoyin cuta da cutar kansar fata ta bayyana a cikin marasa lafiya na RDEB.
Aikin da ke cikin wannan binciken ya nuna cewa tgf-beta sigina da kuma ci gaban ci gaban jijiyoyin jiki na iya zama maƙasudin ci gaban jijiyoyin jini a cikin RDEB SCC. Akwai magungunan da ake amfani da su a cikin hanyoyi guda biyu kuma wannan rukunin yana shirin yin ƙarin aiki don ganin ko ƙaddamar da waɗannan hanyoyin zai taimaka wa marasa lafiya tare da RDEB SCC. Farfesa O'Toole da tawagarta sun buga wata takarda ta kimiyya a cikin Jarida na Cibiyar Ciwon daji ta Kasa a cikin 2016 da ke kwatanta wannan aikin.
"Taimakon da aka samu daga DEBRA UK ya ci gaba da gudanar da binciken mu game da cutar kansar fata da RDEB. Muna sha'awar yin ƙarin aiki don ganin idan hana angiogenesis ya hana ci gaban ƙari a cikin RDEB "
Edel O'Toole asalin
Edel O'Toole asalin
Edel O'Toole farfesa ne na ilimin cututtukan ƙwayoyin cuta da Jagoran Cibiyar Nazarin Kwayoyin Halitta da Cutaneous a Barts da Makarantar Magunguna da Hakora ta London. Ta fara sha'awar collagen da EB lokacin aiki tare da David Woodley a Jami'ar Arewa maso Yamma a Chicago. Ƙungiyarta ta yi aiki a kan RDEB da ciwon daji na fata a cikin shekaru 10 na ƙarshe kuma ta ci gaba da yin aiki don ƙarin fahimtar ciwon daji na fata a RDEB don samun magani mafi kyau ga marasa lafiya.