Maganin fesa baki/maƙogwaro (2022)

An fara bincikar sinadarin carrageenan na halitta azaman sinadari don ƙirƙirar daidaitattun daidaiton feshi don isar da ƙwayoyin halitta masu tsada, decorin da resolvin zuwa cikin bakin. Duk da haka, an gano cewa carrageenan yana da damar da za ta iya magance ta. Yana da arha, mafi aminci kuma mafi sauƙin samuwa, ana samun shi daga ciwan teku kuma ana amfani dashi a yawancin abinci. Ba kamar kwayoyin halitta ba waɗanda ke buƙatar kulawa ta musamman don narke a cikin feshi da kiyaye kayan warkarwa, feshin carrageenan yana da ƙarfi sosai kuma yana da sauƙin shiryawa.

Masu binciken sun yi imanin cewa sinadarin carrageenan da aka haɗe da fesa zai iya taimakawa wajen rage tabo a cikin bakunan mutanen da ke da EB ta hanyar dakatar da ƙwayoyin baki su zama sel masu tabo, dakatar da ƙwayar tabo daga samar da sauri da kuma tasirin sa mai mai don rage rikici lokacin magana da cin abinci. Wannan aikin yana kawo mana mataki kusa da feshin baki don magance alamun EB.

Masu bincike sakamakon da aka buga na aikinsu na fesa magunguna don rage kamuwa da cutar Covid a cikin 2021 kuma sun gabatar da sakamakon a 2022 DEBRA Membobin Burtaniya:

Jagoran bincike:

Liam Grover Farfesa ne a Kimiyyar Biomaterials kuma Daraktan Cibiyar Fasaha ta Kiwon Lafiya a Jami'ar Birmingham UK. Cibiyar Fasahar Kiwon Lafiyar Kiwon Lafiya ta haɗu da manyan masana daga fannoni daban-daban a duk faɗin Jami'ar Birmingham don haɓaka sabbin fasahohi da jiyya waɗanda ke ƙarfafa ingantattun kayan aikin warkarwa da gyaran nama.

Masu bincike: 

Tony Metcalfe Farfesa ne na warkar da raunuka a Jami'ar Birmingham. Tony ya yi aiki a cikin masana'antu, masana'antu da kuma sassan da ba riba ba kuma bincikensa ya mayar da hankali kan gyaran nama, magungunan fassara da warkarwa kyauta.

Ina Chapple shi ne Farfesa na Periodontology kuma Shugaban Makarantar Dentistry a Jami'ar Birmingham UK kuma mai ba da shawara a cikin Restorative Dentistry. Yana jagorantar wata ƙungiya mai ƙarfi a matsayin wani ɓangare na Ƙungiyar Bincike na Periodontal na Birmingham, kuma shine Daraktan Bincike na Cibiyar Nazarin Kimiyyar Clinical a Jami'ar Birmingham. Iain yana gudanar da sabis na baka na asibiti na ƙasa da sabis na hakori don manya EB marasa lafiya tare da haɗin gwiwa tare da Adrian Heagerty, mai ba da shawara akan fata da EB gwani, kuma shine jagorar aikin DEBRA UK da ke tallafawa don ƙarin fahimtar microbiome fata a EB.

Adrian Heagerty Mashawarcin Likitan fata ne a Asibitocin Jami'ar Birmingham NHS Trust kuma kuma Farfesa mai girma na ilimin cututtukan fata a Cibiyar Kumburi da tsufa a Jami'ar Birmingham. Farfesa Heagerty a halin yanzu yana aiki kan ayyukan bincike da yawa don inganta rayuwar mutanen da ke fama da cutar ta EB.

Mai haɗin gwiwa:

Farfesa Alan Smith, Daraktan Cibiyar Nazarin Biopolymer, Jami'ar Huddersfield

“Mun yi matukar farin ciki da samun wannan tallafin na DEBRA don aikin mu. Wannan zai ba mu damar haɓaka tsarin isar da feshin mu wanda muka yi imanin zai iya zama babban fa'ida ga masu fama da epidermolysis bullosa.

Farfesa Liam Grover

“Muna matukar godiya ga DEBRA saboda goyon bayan da suka bayar wajen bayar da tallafin aikin tsarin isar da feshi. Muna fatan sakamakon aikin zai inganta damar isar da kwayoyin warkewa a cikin baki da kuma inganta rayuwar marasa lafiya da epidermolysis bullosa."

Farfesa Tony Metcalfe

Taken Grant: Tsarin bayarwa na sabon labari don maganin tabon mucosal a cikin epidermolysis bullosa.

Wannan aikin zai yi aiki don haɓaka sabon tsarin isar da feshi azaman duka jiyya da dabarun rigakafi don tabo wanda ke shafar mucosa ko membranes a cikin jiki wanda ke nuna EB, da cututtukan da ke da alaƙa. Manufar gabaɗaya ita ce tsara wannan tsarin bayarwa ta yadda za a iya amfani da shi don isar da ƙwayoyin rigakafin fibrotic na ɗan takara guda uku. Mahimmanci, fitowar karshe na aikin za ta kasance tsarin uku da aka tsara da kuma ƙera su ta hanyar da za ta ba da damar yin amfani da su a cikin gwaji na asibiti, wanda za a ba da kuɗi ko dai ta hanyar kasuwanci ko ta hanyar ƙarin aikace-aikacen tallafi.

Babban makasudin wannan aikin shine:

1. Ƙirƙira, tare da likitoci da ƙungiyoyin haƙuri, feshin baki wanda za a iya amfani da shi don bayarwa a cikin rami (ƙunci).
2. Cike kwayoyin antifibrotic na warkewa a cikin wannan kayan kuma suna nuna ikonsu na warkewa a cikin lokacin ajiya sannan a fesa.
3. Ƙirƙirar tsarin GMP (Kyakkyawan Ƙarfafa Ƙarfafawa) don ƙira da cika kayan da ke ɗauke da magunguna.
4. Sanya takaddun da ake buƙata don gwajin lokaci na shiri na baka.

Dukkanin makasudin da ke sama ana iya cimma su a cikin aikin na shekaru biyu da aka ba su 1) sun gudanar da ainihin shirye-shiryen fasahar gel mai feshi, da 2) haɓaka hanyoyin GMP don kera kayan da muke ba da shawarar amfani da su don fesa. Bugu da ƙari, sun riga sun gudanar da gwajin daidaituwa na kayan aiki a cikin layi tare da ISO 10993 (ma'aunin masana'antu don gwajin halittu, sarrafa haɗari da kimantawa), kuma sun yi gwajin hulɗar ɗan adam a cikin fata mara kyau. Dukansu suna ba da damar amfani da shirye-shiryen a cikin ɗan gajeren lokaci.

Manufar wannan aikin shine a samar da wani sabon feshi wanda zai taimaka wajen hana tabon bakin da da yawa daga cikin al’ummar EB ke fuskanta bayan ci, sha, ko goge hakora. Muna son feshin ya ba da kyau ko da ɗaukar hoto na yankin, sannan ya manne a cikin bakin, maimakon gudu kai tsaye. Wannan zai ba da damar ƙwayoyin cuta don yin aikin su yadda ya kamata.

Mun nuna cewa nau'in kwayoyin halitta da ake kira polysaccharides, wanda ke faruwa a dabi'a kuma sau da yawa ana haɗa su a cikin kayan abinci, yana nuna ƙarfin anti-fibrotic mai karfi, tare da mafi karfi shine carrageenan, wanda aka samo daga ciyawa. Don yin wannan, mun kafa samfurin inda muke shuka ƙwayoyin fibroblast na ɗan adam (wani nau'in tantanin halitta da ake samu a cikin fata da cikin baki) a cikin tasa, kuma mu fallasa su ga kwayoyin da ke inganta tabo. Wannan yana haifar da canje-canje da yawa a cikin fibroblasts, ciki har da kwayoyin halittar da suke bayyanawa, da kuma sunadaran da suke samarwa. Sa'an nan kuma mun gabatar da polysaccharides daban-daban a cikin tsarin, kuma mun nuna yawancin su sun rage kwayoyin halitta da sunadaran da ke hade da tabo.

Mun kuma nuna cewa polysaccharides na mu na iya tsoma baki tare da samuwar collagen - da yawa collagen, dage farawa da sauri da yawa, shine abin da jiki ke haifar da tabo. Yawancin polysaccharides namu sun sami damar rage samuwar fibril collagen, ko hana shi gaba ɗaya.

Bayan mun nuna cewa carrageenan, polysaccharide mafi inganci, shine kwayar cutar da ke da tasiri mai karfi, sai muka dubi abubuwan kayan aiki; muna son wani abu zai fesa, amma kuma yana da kauri ko ma mai kauri, wanda zai dade a cikin bakin. A babban taro, maganin carrageenan suna da kauri, amma suna fesa sosai. Saboda haka mun duba hanyoyin da za a inganta sprayability, yayin da rike kauri. Mun kalli dabaru guda biyu; haɗuwa tare da polysaccharide na biyu, da yin amfani da gishiri don canza tsarin carrageenan a ƙananan sikelin. Mun nuna cewa gaurayar polymer ta ƙara yawan fesawa da mannewa zuwa cikin bakin, kuma ɗaya daga cikin abubuwan da aka yi na gishiri kuma ya haɓaka yankin feshi, da kuma inganta yanayin mai. Wannan yana da mahimmanci saboda zai rage ɓacin rai a cikin baki wanda ke farawa da kumburi kuma a ƙarshe yana haifar da tabo.

Muna tsammanin cewa sabbin kayan da muke fesawa da kuma mannewa a cikin baki, na iya taimakawa wajen rage tabo a bakunan masu ciwon EB ta hanyoyi uku; dakatar da ƙwayoyin baki su zama sel masu tabo, dakatar da kwanciya da sauri na collagen, da mai don rage rauni. Waɗannan kayan kuma suna da fa'idodi masu yawa na asali, kamar ƙarancin farashi, kwanciyar hankali mai kyau na dogon lokaci, aminci da aka sani (yawancinsu an yi amfani da su a cikin abinci shekaru da yawa). Wannan kuma yana ba su sauƙi don yinwa da motsa bututun zuwa gwaji na asibiti da kuma cikin mutane, da fatan inganta ingancin rayuwa a cikin al'ummar EB. (Daga rahoton ƙarshe na 2022.)