Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
Brunton 1 (2018)
Ƙayyadaddun rawar kindlin-1 a cikin ka'idojin kwanciyar hankali na microtubule da mitosis.
Game da kudaden mu
| Jagoran Bincike | Farfesa Valerie Brunton, Farfesa na Ciwon daji |
| Institution | Cibiyar Nazarin Ciwon daji ta Edinburgh, Cibiyar Nazarin Halittu da Magungunan Kwayoyin Halitta, Jami'ar Edinburgh |
| Nau'in EB | Epidermolysis Bullosa, Kindler Syndrome |
| Hanyar haƙuri | N / A |
| Adadin kuɗi | £191 |
Bayanan aikin
Kindler ciwo (KS), mai suna bayan likitan da ya fara bayyana shi, wani nau'i ne na epidermolysis bullosa (EB) wanda fata ba ta da ƙarfi, mai kula da haske da blisters don amsawa ga rauni. Yayin da mutum ya tsufa, fatar jikinsu ta zama siriri, yana sa ta zama mai rauni. Marasa lafiya tare da KS suma sun fi saurin kamuwa da wani nau'in ciwon daji na fata da ake kira squamous cell carcinoma. KS yana faruwa ne ta hanyar gadon kuskure a cikin kwayar halittar da ake kira KYAUTA 1 (ko FERMT1) wanda yawanci ke sarrafa samar da furotin: Kindlin-1. Wannan furotin na musamman yana da mahimmanci a cikin tsarin rarraba tantanin halitta (wanda aka sani da mitosis) da girma a cikin ƙwayoyin fata. Halin da ba daidai ba zai samar da furotin Kindlin-1 wanda ba ya aiki yadda ya kamata, yana ba da gudummawa ga bakin ciki da fata mai rauni. Duk da haka, hanyar da Kindlin-1 ke ba da gudummawa ga waɗannan matakai a matakin kwayoyin ba a fahimta ba tukuna.
An fahimci cewa Kindlin-1 furotin ne na 'adaptor', wanda ke nufin yana aiki ta hanyar ɗaure wasu sunadaran da ke cikin tantanin halitta. Wannan aikin yana so ya fahimci yadda Kindlin-1 ke hulɗa tare da sauran sunadaran da ke da hannu a rarraba tantanin halitta. Kungiyar tana da dabaru a dakin gwaje-gwajensu da ke ba su damar gane irin sunadaran da ke hulda da juna da kuma inda a cikin tantanin halitta ke yin mu'amala.
Kwayoyin fata na yau da kullun an kwatanta su da waɗanda daga mutanen da ke da KS don samun fahimtar matakai a cikin rarraba tantanin halitta waɗanda ba sa aiki da kyau a cikin fatar KS. Yi aiki don ƙara fahimtar yadda ayyukan Kindlin-1 ke ba da gudummawa ga ikonmu na ƙirƙira hanyoyin da za mu iya magance wannan cuta.
Bayanan farko sun nuna cewa rashin Kindlin-1 ya rage yawan adadin kwayoyin da ke iya shiga ta hanyar rarraba tantanin halitta (mitosis) don haka, ninka, wanda zai iya yin lissafin fata na bakin ciki (atrophic) da aka gani a cikin marasa lafiya na KS. Ci gaba da bincike kan tsarin rarraba tantanin halitta ya nuna cewa Kindlin-1 yana sarrafa kwanciyar hankali na microtubule. Microtubules suna da hannu wajen kiyaye tsarin tantanin halitta kuma sune babban bangaren "spindle" na mitotic kuma ana buƙatar su raba chromosomes a lokacin mitosis wanda ya ba da damar sel su rarraba cikin nasara da daidai. Ƙaƙwalwar mitotic tana da babbar dama ta zama mara kyau da rashin kwanciyar hankali a cikin sel marasa Kindlin-1. Kindlin-1 yana da mahimmanci yayin da yake taimakawa wajen samar da kwanciyar hankali ta hanyar ɗaure zuwa microtubules, mai mahimmanci don kiyaye tsarin tsarin tantanin halitta da sel. A cikin KS inda fatar marasa lafiya ba ta da Kindlin-1, akwai raguwar rarraba tantanin halitta, ƙananan ƙwayoyin da muka sani yanzu na iya haifar da fata mai bakin ciki ko atrophic.
Don ƙarin fahimtar abin da sauran sunadaran Kindlin-1 ke ɗaure su yayin rarraba tantanin halitta; tawagar ta gudanar da cikakken bincike. Bayan gano abokan hulɗa na Kindlin-1, sun tabbatar da cewa Kindlin-1 yana ɗaure zuwa mahimmin mai sarrafa ci gaban tantanin halitta mai suna CDK. CDK yana sarrafa jigilar sel ta hanyar zagayowar tantanin halitta wanda shine tsarin da sel ke rarraba.
Sun kuma gano cewa sel daga fatar marasa lafiya tare da KS sun fi kula da lalacewar Ultra Violet (UV). UV irradiation (hasken rana) yana haifar da lalacewa ga DNA kuma yana haifar da mutuwar sel kuma Kindlin-1 yana iya kare sel daga wannan lalacewa. Marasa lafiya na KS sun ƙara ɗaukar hoto wanda ke nufin sun fi kula da hasken UV. Ana tunanin Kindlin-1 yana kare fata daga lalacewar UV ta hanyar kunna hanyoyin tsira a cikin sel. Wadannan hanyoyin tsira jerin sunadaran sunadaran da aka haɗe a cikin sel kuma ayyukansu suna aika siginar rayuwa zuwa sel. Ƙungiyar ta gano irin wannan furotin mai suna ERK wanda ke da hannu a cikin wannan hanyar rayuwa inda Kindlin-1 ke tsara aikin.
Yayin da ƙungiyar ta sami ƙarin koyo game da tsarin salula da ke cikin KS, yanzu suna buƙatar tabbatar da ko, da kuma ta yaya, wasu daga cikin waɗannan sunadaran ko alamomi suna tasiri raunin fata KS. Ƙungiyar tana fatan ta hanyar gano sunadaran ko alamomi masu goyan bayan kwanciyar hankali ko rayuwa, wannan na iya ba mu damar gano maƙasudin jiyya a nan gaba.
Kindlin-1 yana hulɗa tare da microtubules a mitotic spindle - Ladabi na Farfesa Brunton
"Bincikenmu ya gano yadda Kindlin-1 ke sarrafa mahimman matakai a cikin sel waɗanda ke ba su damar girma da kuma kare kansu daga lalacewar UV. Yanzu muna buƙatar fahimtar yadda za mu iya dawo da waɗannan hanyoyin a cikin mutanen da ke da KS don samar da jiyya da ake buƙata sosai. "
Farfesa Valerie Brunton
Farfesa Valerie Brunton ita ce Shugabar Kula da Ciwon daji a Jami'ar Edinburgh. Abubuwan da ta ke so shine fahimtar ilimin halitta na Ciwon daji na Kindler, atrophy fata (rauni) da kuma ɗaukar hoto tare da haɓakar haɗarin kamuwa da cutar kansar squamous cell. Binciken nata yana da nufin gano mahimman hanyoyin ƙwayoyin ƙwayoyin cuta waɗanda ke ƙarƙashin ilimin cututtukan cututtukan ƙwayar cuta na Kindler don taimakawa gano hanyoyin da za a bi da wannan cuta.