Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
KEB da kansar fata (2024)
Fahimtar girma da yaduwar cutar kansar fata a cikin KEB zai taimaka wajen gano yuwuwar jiyya a nan gaba.
Farfesa Valerie Brunton yana aiki a Edinburgh, UK, akan wani nau'in epidermolysis bullosa (EB) da ba kasafai ake kira ba. Farashin EB. Wannan yana faruwa ne ta hanyar canje-canjen kwayoyin halitta wanda ke nufin furotin Kindlin-1 baya aiki da kyau. Marasa lafiya da ke fama da wannan nau'i na EB suna da fata mai bakin ciki wanda blisters da kunar rana a cikin sauƙi da kuma ƙara haɗarin ciwon daji na fata (squamous cell carcinoma). Wannan aikin yana nazarin yadda girma da yaduwar cutar kansar fata ke da alaƙa da furotin Kindlin-1.
Game da kudaden mu
| Jagoran Bincike | Farfesa Valerie Brunton |
| Institution | Jami'ar Edinburgh, Birtaniya |
| Nau'in EB | KEB |
| Hanyar haƙuri | Babu |
| Adadin kuɗi | £230,271.67 (haɗin gwiwa tare da DEBRA Austria) |
| Tsawon aikin | shekaru 3 (tsawaita saboda Covid) |
| Fara kwanan wata | Oktoba 2020 |
| DEBRA ID na ciki | Brunton 2 |
Bayanan aikin
Sakamako na 1: Kwayoyin ciwon daji tare da canjin kwayoyin halitta na KEB (rashin kindlin-1) an nuna su da yiwuwar haifar da ciwon daji na biyu a wasu sassan jiki.
Sakamakon 2: Waɗannan ƙwayoyin suna da matakan furotin da ke da alaƙa da yaduwar cutar kansa. Rage wannan furotin a cikin sel ya rage ikon su na haifar da ciwon daji kuma wannan zai iya zama tushen jiyya na gaba don ciwon daji na squamous cell a cikin EB.
Sakamakon 3: Sakamakon farko ya nuna cewa hasken UV yana ƙaruwa da sunadaran da ke cikin kumburi a cikin kwayoyin cutar kansa. Yana ƙara kaurin fata (epidermis) tare da haɓaka girma a cikin adadin ƙwayoyin fata (keratinocytes) kama da farkon ciwon daji na girma.
Wannan aikin ya kasance An buga shi a cikin mujallar Oncogenesis A cikin 2024. An gabatar da shi a cikin tattaunawar ga taron shekara ta Burtaniya ga taron kwararru a cikin 2022 kuma, a cikin gabatarwar Scotting Skinistsium Schoseum a 99.
Jagoran bincike:
Farfesa Valerie Brunton ita ce Shugabar Kula da Ciwon daji a Jami'ar Edinburgh. Abubuwan da ta ke so shine fahimtar ilimin halitta na Kindler EB da ke hade da atrophy fata (raunana), daukar hoto, da kuma haɗarin haɓaka ciwon daji na squamous cell. Binciken nata yana nufin gano mahimman hanyoyin ƙwayoyin ƙwayoyin cuta waɗanda ke ƙarƙashin ilimin cututtukan Kindler EB don taimakawa gano hanyoyin da za a bi da wannan.
Masu bincike:
Dr Adam Byron (biochemistry) Jami'ar Edinburgh da Farfesa Albena Dinkova-Kostova (maganin salula) Jami'ar Dundee.
Mai haɗin gwiwa:
Dr Alan Serrels (ciwon daji / ƙari microenvironment) Jami'ar Edinburgh.
"Bincikenmu ya gano muhimman canje-canje a cikin ƙananan ƙwayoyin cuta (kwayoyin halitta na yau da kullum da kwayoyin da ke kewaye da kuma tallafawa ci gaban ƙwayoyin tumo), wanda Kindlin-1 ke sarrafawa. Ta hanyar nazarin waɗannan canje-canje, muna fatan samun kyakkyawar fahimtar yadda za mu iya hana ci gaba da ci gaban ciwon daji na fata a cikin marasa lafiya da ke fama da ciwon Kindler. "
– Farfesa Valerie Brunton
Taken Grant: Fahimtar rawar da asarar Kindlin-1 ke takawa a cikin ci gaban ciwon daji na squamous cell
Kindler EB (KEB) cuta ce ta fata da ba kasafai take tasowa ba a farkon rayuwa. Mutanen da ke da KEB suna da kumburin fata kuma suna tasowa siriri ko fata mai takarda. Hakanan suna da matukar damuwa ga hasken ultraviolet (UV) daga rana da kunar rana cikin sauƙi. KEB kuma yana ƙara haɗarin kamuwa da nau'in ciwon daji na fata mai suna squamous cell carcinoma. KEB yana faruwa ne saboda maye gurbi a cikin jigon FERMT1. Maye gurbi a cikin FERMT1 yana haifar da samar da furotin mara kyau da ake kira Kindlin-1.
A halin yanzu ba a san kaɗan ba game da dalilin da yasa asarar furotin Kindlin-1 mai aiki a cikin fata na mutanen da ke da KEB yana ƙara haɗarin kamuwa da ciwon daji na squamous cell carcinoma (SCC). A baya kungiyar ta gudanar da gwaje-gwaje a kan ƙwayoyin fata da aka girma a cikin dakin gwaje-gwaje wanda ya nuna cewa asarar Kindlin-1 yana sa ƙwayoyin sel zuwa UV radiation. Don fahimtar dalilin da yasa hakan ke faruwa za su yi amfani da samfurin da ke kwaikwayi faɗuwar rana ga UV radiation. Mataki na gaba zai duba ko asarar Kindlin-1 a cikin fata yana haifar da haɓakar ciwon daji na fata bayan bayyanar UV.
Manufofin wannan aiki guda 3 sune:
- Shin canje-canje a cikin yanayin nama na ciwace-ciwacen da ba su da Kindlin-1 suna ba da gudummawa ga haɓakarsu da yaɗuwar metastatic?
- Shin Kindlin-1 abokan haɗin gwiwa (kwayoyin da ke hulɗa), suna daidaita haɓakar ciwon daji (SCC)?
- Shin asarar Kindlin-1 yana haɓaka samuwar cutar kansar fata ta UV (SCC)?
DEBRA UK a baya kudade Farfesa Valerie Brunton a Jami'ar Edinburgh game da bincike a cikin ciwon Kindler.
Kindler EB (KEB) cuta ce ta fata da ba kasafai take tasowa ba a farkon rayuwa. Mutanen da ke da KEB suna da kumburin fata, kuma suna tasowa siriri ko fata mai takarda. Hakanan suna da matukar damuwa ga hasken ultraviolet (UV) daga rana da kunar rana cikin sauƙi. KEB kuma yana ƙara haɗarin kamuwa da nau'in ciwon daji na fata da ake kira squamous cell carcinoma. KEB yana faruwa ne saboda maye gurbi a cikin jigon FERMT1. Maye gurbi a cikin FERMT1 yana haifar da samar da furotin mara kyau da ake kira Kindlin-1. A halin yanzu ba a san kaɗan ba game da dalilin da yasa asarar furotin Kindlin-1 mai aiki a cikin fata na mutanen da ke da KEB yana ƙara haɗarin kamuwa da ciwon daji na squamous cell. A baya mun gudanar da gwaje-gwaje a kan ƙwayoyin fata da aka girma a cikin dakin gwaje-gwaje wanda ya nuna cewa asarar Kindlin-1 yana sa ƙwayoyin sel zuwa UV radiation. Don fahimtar dalilin da ya sa hakan ke faruwa za mu yi amfani da samfurin da ke kwaikwayi faɗuwar rana ga UV radiation. Wannan zai gano canje-canjen da UV ta haifar waɗanda asarar Kindlin ke sarrafawa ta musamman. Mataki na gaba zai duba ko asarar Kindlin-1 a cikin fata yana haifar da haɓakar ciwon daji na fata bayan bayyanar UV (Daga rahoton ci gaba na 2022 & 2023 da rahoton ƙarshe na 2024).