Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
TGF-β siginar a cikin RDEB Squamous Cell Carcinoma
Dystrophic epidermolysis bullosa (DEB) cuta ce ta kwayoyin halitta wacce ke sa fata ta yi rauni sosai, tare da nau'in recessive (RDEB) yana haifar da kumburi mai tsanani da jinkirin warkarwa. Yawancin mutanen da ke tare da RDEB suna haɓaka squamous cell carcinoma (SCC), ciwon daji mai kisa. Masu bincike sun gano cewa hanyar siginar TGF-β (Transforming Growth Factor Beta), wanda ke taimakawa sarrafa ci gaban kwayar halitta, ya rushe a cikin fata na marasa lafiya na RDEB, musamman a cikin kwayoyin da ke kusa da ciwon daji. Wannan binciken yana nufin fahimtar yadda wannan rushewar ke ba da gudummawa ga haɓakar ciwon daji, mai yuwuwar haifar da ingantattun jiyya ta amfani da magungunan da ke da alaƙa da hanyar TGF-β.
Game da kudaden mu
| Mai Bincike | Dr Gareth Inman, Dr Andrew South |
| Institution | Sashen Binciken Ciwon daji, Cibiyar Nazarin Likita, Kwalejin Magunguna, Dentistry da Nursing, Jami'ar Dundee. |
| Nau'in EB | RDEB |
| Hanyar haƙuri | N / A |
| Adadin kuɗi | £190,284 |
| Tsawon aikin | 3 shekaru |
| Fara kwanan wata | 01/12/2014 |
| Ƙarshen kwanan wata | 30/11/2017 |
Bayanan aikin
Dystrophic epidermolysis bullosa (DEB) cuta ce da aka gada wacce za ta iya zama mafi rinjaye (mahaifiya ɗaya ke wucewa akan kwayar halittar da ba ta dace ba) ko kuma ta koma baya (iyaye biyu suna yin gadon gado mara kyau) gada. Mafi girman nau'in ba a haɗa shi da matsalolin asibiti masu tsanani, amma nau'in recessive (RDEB) yana sa mutum ya sami fata mai rauni wanda ke fitowa cikin sauƙi, yana warkarwa a hankali kuma yana da wuyar samun tabo mai yawa. Matsaloli kuma na iya faruwa a cikin baki da tsarin narkewar abinci. Wani mawuyacin hali shine yawancin mutanen da ke da RDEB zasu haifar da ciwon daji na fata da ake kira squamous cell carcinoma (SCC), wanda sau da yawa yakan mutu.
Ana sarrafa duk aikin tantanin halitta ta sigina da ake wucewa ciki da tsakanin sel. Wannan rukunin bincike kwanan nan ya nuna cewa takamaiman tsarin sigina, wanda ya haɗa da kwayoyin halitta mai suna Transforming Growth Factor- β (TGF-β), yana da matukar rauni a cikin fatar mutanen da ke da RDEB. A cikin ciwon daji, hanyar TGF-β ba ta aiki yadda ya kamata, don haka sel su fara girma da rarraba ta hanyar da ba a sarrafa su ba, aikin TGF-β kuma na iya rushewa a cikin sel da ke kewaye da ƙwayar cuta. Wannan yana da mahimmanci tun da akwai hulɗa mai yawa tsakanin ƙwayoyin cutar kansa da sel makwabta (wanda ake kira cross-talk) wanda sau da yawa yana taimakawa kwayoyin cutar kansa suyi girma. Wani lokaci kwayoyin cutar kansa suna aika sakonni zuwa sassan da ke kewaye da su don kashe martanin da zai lalata kwayoyin cutar kansa, ko don inganta haɓakar jini, wanda ke tallafawa da kuma ciyar da ciwon daji.
Wannan rukunin ya nuna a baya cewa yayin da ƙwayoyin kansa na RDEB suna da TGF-β na al'ada, ƙwayoyin da ke kewaye ba su. Saboda haka, wannan aikin yana bincikar ko ƙwayoyin da ke kewaye da su ne ke tallafawa ciwon daji ko kuma idan magana ce tsakanin kwayoyin cutar kansa da kwayoyin da ke kewaye da su suna sa ciwon daji ya girma.
Akwai wasu magunguna waɗanda ke kaiwa hanyoyin TGF-β a cikin amfani da asibiti. Idan wannan aikin zai iya bayyana yadda aka canza hanyoyin TGF-β a cikin SCC a cikin marasa lafiya na RDEB to yana iya yiwuwa a fahimci yadda za mu iya amfani da waɗannan kwayoyi don magance EB SCC, da kuma samar da tushe don ƙarin fahimtar siginar kwayar halitta da miyagun ƙwayoyi. ci gaba.
Dr Gareth Inman
Dr Gareth Inman mai karatu ne a Jami'ar Dundee, Scotland. Babban abin da ya fi so shi ne fahimtar irin rawar da membobin kungiyar Beta (TGFb) ke takawa wajen bunkasa ciwon daji da ci gaba. Nazarinsa ya mayar da hankali kan squamous cell carcinoma na kai, wuyansa da fata kuma yanzu ya haɗa da waɗannan cututtukan daji da ke tasowa a cikin marasa lafiya da ke zaune tare da recessive dystrophic epidermolysis bullosa. Ta hanyar fahimtar matsayin TGFb a matsayin duka mai tallata kansa da mai hana kansa Dr Inman yana fatan haɓaka waɗannan binciken don maganin kansar.
“Muna farin cikin koyon yadda ƙwayoyin kansa ke hulɗa da muhallinsu. Tare da ƙarin karatu za mu iya yin amfani da wannan ilimin don haɓaka jiyya don ciwon daji na EB."
Dr Gareth Inman