Wannan shafin yanar gizon yana amfani da kukis domin mu iya ba ku damar kwarewa mafi kyau. Ana adana bayanin kuki a cikin burauzarka kuma yana aiki da ayyuka kamar gane da ku idan kun dawo zuwa shafin yanar gizon mu da kuma taimaka wa tawagar mu fahimci wane ɓangaren shafin yanar gizon da kuka samu mafi ban sha'awa da amfani.
PhD: haɓaka YAP/TAZ don hanzarta warkar da rauni
Binciken tabbataccen ra'ayi don tantance sabbin damar warkewa don ingantacciyar warkar da rauni.
Dokta Walko yana aiki a Jami'ar Queen Mary ta London (QMUL), Birtaniya, yana kula da wannan aikin na PhD wanda zai horar da sabon mai binciken EB.
Manufar ita ce samar da hujja-na-ra'ayi don sabon nau'in magani wanda ake fatan zai ƙara yawan ƙwayoyin da ke motsawa zuwa wuraren da aka lalatar da fata JEB.
Game da kudaden mu
| Jagoran Bincike |
Dr Gernot Walko |
| Institution |
Jami'ar Sarauniya Mary ta Landan/Bangaren Magunguna da Dentistry/Cibiyar Dentistry/Cibiyar Immunobiology na Baka da Magungunan Farfaɗo |
| Nau'in EB | JEB |
| Hanyar haƙuri | A'a |
| Adadin kuɗi |
£139,962 haɗin gwiwa tare da DEBRA Faransa |
| Tsawon aikin | 4 shekaru |
| Fara kwanan wata | TBC 2025 |
| DEBRA ID na ciki |
GR000077 |
Bayanan aikin
Domin 2026.
Jagoran bincike:
Dokta Gernot Walko Babban Malami ne (Mataimakin Farfesa) a Cibiyar Immunobiology na Oral da Magungunan Farfadowa a Cibiyar Nazarin Hakora ta Jami'ar Sarauniya Mary ta London (QMUL). Dokta Walko ya yi digirinsa na uku a rukunin Farfesa Gerhard Wiche a Jami'ar Vienna (Ostiraliya), inda bincikensa ya mayar da hankali kan hanyoyin kwayoyin da ke tattare da cututtukan fata irin na EB EBS-MD da EBS-Ogna. A cikin 2013, Dokta Walko ya shiga ƙungiyar binciken ilimin halittun fata na duniya na Farfesa Fiona Watt a Kwalejin King London (Birtaniya) inda bincikensa ya mayar da hankali kan hanyoyin kwayoyin da ke sarrafa sabuntawar kai na kwayoyin halitta na epidermal. Dr Walko ya ci gaba da bibiyar aikinsa na bincike mai zaman kansa, na farko a Jami'ar Bath (2018-2024), kuma yanzu a QMUL.
Masu bincike:
Dokta Emanuel Rognoni Babban Malami ne (Mataimakin Farfesa) a Cibiyar Nazarin Halittar Halittu da Cutaneous Biology a Cibiyar Blizard ta QMUL tare da> 14 shekaru gwaninta a binciken nazarin halittun fata.
Dokta Matthew Caley babban malami ne (Mataimakin Farfesa) a Cibiyar Nazarin Halittar Halitta da Cutaneous Biology a Cibiyar Blizard ta QMUL tare da fiye da shekaru goma na gwaninta a binciken fata.
A cikin haɗin gwiwar:
Farfesa Jason Carroll, FMedSci, Farfesa na Molecular Oncology da Babban Jagora a Cibiyar Nazarin Ciwon daji ta UK Cambridge Institute, Jami'ar Cambridge, Birtaniya.
Dr Angus Cameron babban mai bincike ne kuma Mataimakin Farfesa (Mai karatu) a Cibiyar Ciwon daji ta Barts ta QMUL.
"Bayanan da aka samar a cikin wannan aikin ɗalibin PhD zai sa mu cikin kyakkyawan matsayi don fassara abubuwan da muka gano a cikin maganin warkar da raunuka ga fata JEB, da zarar YAP / TAZ-mai kunna mahadi suna shiga gwaji na asibiti."
– Dr Gernot Walko
Taken baiwa: Haɓaka ƙarfin farfadowa na Junctional EB fata ta sake kunna siginar YAP/TAZ.
Junctional epidermolysis bullosa (JEB) cuta ce ta fata da ba kasafai ba ke haifar da kumburi mai yaduwa da raunin rauni. Wannan yana faruwa ne ta hanyar asarar mahimman sunadaran da ke ɗaure murfin fata zuwa sauran jiki. Mafi tsanani nau'i, JEB mai tsanani, yana faruwa ne ta hanyar asarar aikin furotin da ake kira laminin-332, wanda shine mahimmin sashi na sassan jikin fata. Marasa lafiya tare da JEB suna fama da gazawar ci gaba, rashin warkar da rauni, matsanancin ciwon fata, da haɗarin guba na jini (sepsis).
Rashin warkar da fata na JEB yana da alaƙa da raguwar matakan sunadaran sunadarai guda biyu da ake kira YAP da TAZ a cikin ƙwayoyin fata. YAP/TAZ yakan yi aiki a cikin tsakiya na tantanin halitta inda suke haɓaka maganganun kwayoyin halitta waɗanda ke ba da damar ƙwayoyin fata su ninka kuma suyi ƙaura don amsawa ga raunin fata. Kwanan nan, an ƙirƙira magungunan magunguna da yawa waɗanda zasu iya haɓaka matakan nukiliya na YAP/TAZ ta hanyar toshe siginoni mara kyau na sama. A cikin wannan ɗaliban PhD, za mu bincika idan waɗannan mahadi za a iya amfani da su don (i) sake kunna kalmar YAP / TAZ ta nukiliya a cikin ƙwayoyin fata na JEB (Aim-1), da (ii) don haka inganta lafiyar fata da kuma hanzarta warkar da rauni. (Manufa-2&3).
Wannan binciken tabbatar da ra'ayi zai ƙayyade idan sake kunna YAP/TAZ na wucin gadi a cikin fata na JEB zai iya ba da dama na warkewa na zamani don ingantacciyar warkar da rauni. Wannan binciken zai sanya mu cikin matsayi na bincike na sake amfani da miyagun ƙwayoyi sau ɗaya ana gwada masu kunna siginar YAP/TAZ a cikin gwaje-gwajen asibiti don aikace-aikacen magani na farfadowa.
Domin 2026.