Tsallake zuwa content

Hickerson 2 (2019)

Isar da maganin antisense oligonucleotides zuwa basal Layer ta amfani da duban dan tayi

Takaita aikin

Bincika amfani da Ultrasound azaman Tsarin Isarwa don Epidermolysis bullosa simplex Therapy

Game da kudaden mu

Jagoran Bincike Dokta Robyn Hickerson, Dr. Michael Conneely da Farfesa Irwin McLean
Institution Sashen Kimiyyar Halittu da Gano Drug, Makarantar Kimiyyar Rayuwa, Jami'ar Dundee
Nau'in EB EBS
Hanyar haƙuri N / A
Adadin kuɗi £8,500
Tsawon aikin 1 shekara
Fara kwanan wata Q3 2018
Ƙarshen kwanan wata Q2 2019

Bayanan aikin

Epidermolysis bullosa simplex (EBS) yana haifar da kurakurai a ciki Saukewa: KRT5 da kuma Saukewa: KRT14; Kwayoyin halitta guda biyu waɗanda ke ƙididdige sunadaran sunadaran keratin 5 da 14, waɗanda ke da mahimmanci ga amincin tsarin fata. Kowa yana dauke da kwafi biyu na wadannan kwayoyin halitta, daya gada daga mahaifiyarsa, daya daga mahaifinsa. Maye gurbi ko kuskure a cikin DNA a cikin ɗayan kwafin biyu kawai ya isa ya haifar da EBS. Samar da furotin a cikin fata, misali keratin 14 daga Saukewa: KRT14 kwayoyin halitta, ana yin sulhu ta hanyar kwayar halitta da ake kira da Saukewa: KRT14 manzo RNA kuma wannan aikin yana duban niyya ga wannan manzo don hana gina jiki mara kyau.

Kwayoyin da ake kira antisense oligonucleotides (ASOs) ana iya tsara su don ɗaure su da haɓaka lalata takamaiman RNAs na manzo. Waɗannan su ne zanen kwayoyin halitta na roba. Saboda yadda suke aiki, za su iya ba da magani wanda zai iya dakatar da tsarin cututtuka na EBS, ta hanyar hana manzo yin nau'in furotin mara kyau. A Dundee, ƙungiyar tana bin hanyar da ke amfani da ASOs don dakatar da kuskure Saukewa: KRT14 manzo RNA

Tare da WAVE Lifesciences (kamfanin harhada magunguna a Boston, Amurka), ƙungiyar ta sami damar gano ASO da yawa waɗanda zasu iya lalata kuskuren musamman. Saukewa: KRT14 manzo RNA a cikin kwayoyin fatar jikin mutum da aka girma a cikin dakin gwaje-gwaje. Sun kuma yi maganin fatar mutum (sharar fata bayan tiyata) da wadannan ASOs; duk da haka, ba su yi nasara ba a cikin samfurin fata ya zuwa yanzu mafi kusantar saboda wahalar da ke tattare da kutsawa cikin sashin kariya na fata. Ƙungiyar ta ba da shawarar yin amfani da wasu mitoci na duban dan tayi (da kuma haɗuwa da mitoci) don sadar da ASOs zuwa yankin fata wanda ke samarwa. Saukewa: KRT14 manzo RNA don bincika wannan azaman hanyar isarwa a cikin ƙirar fata. Fata shi ne cewa wannan hanya za ta dauki binciken mataki daya gaba don bunkasa maganin ASO kuma mai yiwuwa zuwa fahimtar ilimin halitta na fata a cikin EBS.

Dr. Robyn Hickerson

Hoton kai na Robyn Hickerson, yana murmushi a kyamara

Binciken farko na Robyn Hickerson ya mayar da hankali kan gano magunguna don cututtukan fata da ba safai ba. Babban hannun wannan shirin yana mai da hankali ne kan hanyoyin kwantar da hankali na tushen nucleic acid - musamman haɓaka dabarun sadar da waɗannan yuwuwar hanyoyin warkewa. Tawagar ta ta haɓaka litattafai da na zamani ex vivo samfuran fata na ɗan adam da ake buƙata don kimanta bayarwa da inganci. Tare da shirye-shiryen da aka fi mayar da hankali kan hanyoyin kwantar da hankali ta hanyar haɗin gwiwa tare da Kimiyyar Rayuwa ta WAVE, manufar farko ita ce kawo waɗannan kwayoyin zuwa asibiti a cikin ƴan shekaru masu zuwa.

Baya ga magungunan nucleic acid, Dr. Hickerson kuma yana sha'awar haɓaka ƙananan ƙwayoyin cuta don magance cututtukan fata. Don wannan, ƙungiyarta tana aiki tare da ayyukan haɗin gwiwa guda uku tare da Sashin Gano Magunguna da Cibiyar Nazarin Halittu ta ƙasa, duka a cikin Jami'ar.

Farfesa Irwin McLean

Hoton kai na Irwin McLean, sanye da riga mai shudin sojan ruwa yana murmushi a kyamara

Irwin McLean farfesa ne na ilimin halittar dan adam a Jami'ar Dundee. Ƙungiyar bincikensa ta gano abubuwan da ke haifar da cututtuka na mutane fiye da 20, ciki har da yawancin cututtuka na keratin da kuma haɗin ginin tsarin tsarin epithelial. Musamman ma, yana da sha'awa mai tsawo game da kwayoyin halittar cututtukan fata irin su epidermolysis bullosa simplex (EBS) da ci gaban jiyya don wannan da cututtukan keratin masu alaƙa. Dangane da bincikensa, Irwin ya ci ko an ba shi lambobin yabo da kyaututtuka da yawa na duniya. Ya yi laccoci a duk faɗin duniya kuma an ba shi lambar yabo ta Buchannan ta Royal Society don bayar da gudummawa ta musamman ga ilimin likitanci a cikin 2015.

A cikin 2015, dakin gwaje-gwaje na Irwin ya ƙaura zuwa Sashen Kimiyyar Halittu da Gano Drug, Kwalejin Kimiyyar Rayuwa, Jami'ar Dundee, saboda kusancinsa da Sashin Gano Drug wajen haɓaka maganin cututtukan fata. Har ila yau, Irwin yana da kusanci da Ma'aikatar Kiwon Lafiya ta Ƙasa kuma yana riƙe da Muƙamai na Mashawarcin Likitanci na NHS a cikin Genetics na ɗan adam da kuma a cikin ilimin cututtukan fata. An zabe shi a matsayin Fellow of the Royal Society of Edinburgh (2005), Fellow of the Academy of Medical Sciences (2009) da Fellow of the Royal Society (2014). Irwin yana aiki tare da ƙungiyoyi masu ba da shawara na haƙuri DEBRA, PC Project da sauransu don sadar da tallafin haƙuri, ganewar asali na ƙwayoyin cuta da kuma rajista na abubuwan da aka ayyana ta hanyar gado don ba da damar gwajin asibiti na sabbin magungunan ƙwayoyin cuta.

Dr. Michael Conneely

Hoton kai na Michael Conneely, sanye da rigar lemu, yana murmushi a kyamara. A cikin ƙasa ta baya muna iya ganin tsarin dutsen Giant's Causeway.

Michael Conneely ya sami digirin digirgir a fannin Physics daga Jami'ar Dundee inda ya mai da hankali kan aikace-aikacen duban dan tayi don isar da hanyoyin warkewa a cikin jiki. A cikin shekaru uku da suka gabata ya yi aiki a matsayin ɓangare na ƙungiyar Hickerson da ke haɓaka fasahar zamani ex vivo samfurin fata don amfani a cikin kimantawa na bayarwa da ingancin magungunan warkewa. Bangaren baya-bayan nan na wannan aikin ya haɗa da haɗin gwiwa tare da Cibiyar Nazarin Halittu ta Ƙasa, wani kayan aiki na duniya da ke amfani da sabon abu a cikin dandamali na mutum-mutumi da na atomatik, don tsara tsarin al'adun fata masu yawa don amfani da babban abun ciki (HCS) aikace-aikace.

Dokta Conneely kuma yana yin wasu ayyuka da yawa da suka haɗa da: daidaita sabbin dabarun tarihi don amfani da nama na fata, ba da damar sabbin hanyoyin bincikar tsarin fata da martani ga abubuwan motsa jiki; da kuma yin aiki don inganta jin daɗin haƙuri a cikin rayuwarsu ta yau da kullun ta hanyar daidaita haɗin gwiwa tare da abokan aiki a cikin Physics da Injiniya suna kallon yuwuwar da ƙirar takalman sanyaya.