DEB ciwon daji da kuma bakin rauni warkar

Domin 2025.

Jagoran bincike:

Dokta Inês Sequeira babban malami ne / Mataimakin Farfesa a Ciwon daji na baka kuma Mataimakin Daraktan Bincike a Cibiyar Dentistry a Ginin Blizard a Jami'ar Queen Mary London. A matsayinta na masanin ilimin halitta na Stem Cell fiye da shekaru 18, ta sadaukar da yawancin aikinta na bincike don nazarin fata da epithelia homeostasis na baka, warkar da raunuka da kansa. A halin yanzu tana da hannu a ƙoƙarin duniya na tsara taswirar dukkan ƙwayoyin jikin ɗan adam ta hanyar Human Cell Atlas (HCA) Ƙaddamarwa da daidaitawar Human Cell Atlas Oral da Craniofacial Biological Network wanda aka mayar da hankali kan fahimtar nau'in kwayar halitta na mucosa na baka. Binciken ƙungiyarta yana mai da hankali kan fahimtar ƙarancin ƙwayar mucosa na baka idan aka kwatanta da fata, da kuma tarwatsa nau'ikan salon salula da kwayoyin cutar sankarar baki na squamous cell carcinomas. Dr Sequeira yana da himma sosai a fannin ilimin kimiyya, yana rubutu da yawa bulogin kai tsaye, samar da a podcast akan binciken kwayar halitta, Yin aiki tare da haɗin gwiwar masu fasaha da masu zane-zane don haɓaka kayan aikin fasaha, shirya ziyarar lab ga yara makaranta da ba da jawabi a makarantu. Dangane da waɗannan hanyoyin sadarwa da gogewa, za ta yi aiki tare da al'ummar yankin don raba sakamakon bincikenta.

Masu bincike:

Dokta Christina Guttmann-Gruber da Dr Josefina Piñón Hofbauer shugabannin rukuni ne da manyan masu bincike a EB House Austria, Cibiyar Nazari ta EU don marasa lafiya da epidermolysis bullosa.

Dokta Su Mar Lwin ma'aikacin likitan fata ne kuma Jagoran Rukuni a St John's Institute of Dermatology, Guy's da St Thomas' NHS Foundation Trust da King's College London, bi da bi. Dr Lwin yana da ƙwarewar fiye da shekaru tara a cikin bincike na fassara a cikin cututtukan fata na monoogenic; ita ce GCP (Kyakkyawan Ayyukan Clinical) da HTA (Dokar Nama ta Dan Adam) -wanda aka horar da ita, kuma Babban Mai bincike akan binciken farko na asibiti don haɓaka novel spray-on ex vivo genetherapy don RDEB.

Dr Mirjana Efremova malami ne kuma shugabar rukuni a Cibiyar Ciwon daji ta Bart. Dokta Efremova masanin ilimin halittu ne tare da kwarewa mai zurfi a cikin nazarin bayanai na bayanai masu yawa na kwayoyin halitta guda daya kuma yana da hannu a cikin nazarin bayanan Skin Cell Atlas (aikin Atlas na Mutum). Ta haɗu da haɓaka mai karɓa: ligand cell-cell mu'amala kayan aiki CellPhoneDB da bayanai hadewar algorithm MultiMap.

"Idan kun kasance majinyacin RDEB, kuna rayuwa tare da barazanar ciwon daji da ke gabatowa. Akwai babban bukatu don fassara fahimtarmu game da ilimin halittar RDEB zuwa ikon ganowa, tsinkaya, ko hana lalata wani mummunan rauni a cikin rukunin fibrotic marasa warkarwa kuma cikin ƙari."

- Dr Inês Sequeira

Sunan baiwa: Gano hanyoyin salula da ƙwayoyin cuta waɗanda ke haifar da tabo na mucosal na baka da juriya ga ci gaban kansa a cikin marasa lafiya na RDEB.

Idan kai majinyacin RDEB ne, kana rayuwa tare da barazanar ciwon daji da ke gabatowa. Akwai babban buƙatu don fassara fahimtarmu game da ilimin halitta na RDEB zuwa ikon ganowa, tsinkaya, ko hana lalatawar wani mummunan rauni a cikin rukunin fibrotic marasa warkarwa kuma cikin ƙari. Dabarunmu don magance wannan buƙatu, ita ce duban warkar da raunuka da samuwar cutar kansa daga mahangar musamman na nama (mucosa na baki) wanda galibi yana warkarwa sosai. Wannan ikon ya ɓace a cikin mucosa na baka na RDEB, wanda duk da haka yana nuna juriya ga ci gaban ƙari idan aka kwatanta da fata. Don haka, wannan nama na iya riƙe maɓalli don fahimtar abin da ake buƙata don haɓaka warkar da rauni da kuma hana ciwon daji. Duk da haka, bincike kan mucosa na baki a cikin EB ba shi da yawa. Mun yi niyya don gyara wannan ta hanyar amfani da hanyoyin zamani waɗanda ke ba mu damar haɓaka samun bayanai daga samfurin nama ɗaya, don haka mu mutunta nauyin cutar majiyyaci. Za mu tsara bayanan game da manyan bayanan da aka buga da waɗanda ba a buga ba daga lafiyayyan yara da manya, waɗanda muke da damar yin amfani da su azaman jagorar hanyar sadarwa a cikin ƙungiyar Human Cell Atlas, da kuma sauran kyallen takarda masu kumburi. Wannan yana nufin cewa muna da mafi kyawun damar samun fahimtar ilimin halitta daga ƙayyadadden adadin samfuran haƙuri. Bayananmu za su yi yuwuwar haskaka shirye-shiryen tantanin halitta waɗanda za a iya niyya don jiyya a cikin wani lokaci na bincike na gaba. Za mu samar da bayanan mu a ko'ina don tallafawa ƙarin bincike ta al'ummar EB.

A cikin mutane masu lafiya, raunuka a cikin baki (mucosa na baki) suna warkar da sauri kuma ba tare da tabo ba. Koyaya, a cikin RDEB, marasa lafiya suna fama da raunuka marasa warkarwa da kuma tabo mai zurfi na fata da mucosa na baki. Ta hanyar nazarin bambance-bambancen bambance-bambance a cikin raunin rauni tsakanin mucosa na baki na daidaikun mutane masu lafiya da marasa lafiya na RDEB, za mu iya gano alamun abin da ake buƙata don warkarwa mara tsoro. Za a cim ma wannan ta hanyar amfani da fasahar zamani waɗanda ke ba mu damar gano sel daban-daban waɗanda suka haɗa da nama (watau tsarin salula), da kuma ba da haske ga abin da waɗannan sel suke yi (watau yanayin tantanin halitta). Bugu da ƙari, yayin da marasa lafiya na RDEB ke da wuyar haɓakar ciwace-ciwacen fata, ciwon daji na baka da wuya ya haɓaka a cikin waɗannan marasa lafiya, yana ba da shawarar juriya na asali ga ciwon daji na ƙwayar mucosa na baki wanda zai iya dangantaka da nau'o'in tantanin halitta daban-daban, jihohin tantanin halitta, da yanayin kumburi a yanzu. a baki da fata. Ta hanyar cikakken nazarin tsarin salula da yanayin tantanin halitta na baki da fata, za mu iya gano abubuwan salula da kwayoyin da ke taimakawa wajen warkar da rashin lafiya da kuma juriya na ciwon daji, wanda shine abin da ake bukata don tsara hanyoyin kwantar da hankali don inganta raunin rauni, hana tabo da ciwon daji. samuwar a duka fata da baki a cikin marasa lafiya na RDEB.

Domin 2025.