Maida magunguna don EB
Magance miyagun ƙwayoyi shine dabarar amfani da magungunan da ke akwai don sabon magani ko yanayin likita wanda ba a nuna shi ba a da.
Wannan yana haifar da dama mai ban sha'awa ga mutanen da ke da EB, da sauran yanayi maras tsada kuma, inda tsadar haɓaka sabon magani (har zuwa £ 1b kowace magani) da lokacin kasuwa (shekaru 10-20) galibi yana sa ta kasuwanci. maras kyau ga kamfanonin harhada magunguna.
Mayar da magunguna a kwatanta yawanci farashin har zuwa £ 500k kowace magani kuma yana iya ɗaukar ƙasa da shekaru 2.
Dubi ginshiƙi da ke ƙasa wanda ke kwatanta tsarin lokaci don haɓaka sabon-sabon magani tare da tsarin lokaci mai maimaita magani.
Da farko ana yin gwajin asibiti akan mutane kaɗan ne kawai idan aka sami wasu illolin da ba a zata ba, ana kiran wannan da kashi na 1. Idan wannan lokaci ya nuna cewa sabon magani ba shi da lafiya, to ana iya gwada shi akan ƙarin mutanen da ke da alamun cutar. a cikin gwaji na lokaci 2. Koyaya, idan an riga an fara amfani da maganin da ake gwadawa kuma an sami nasarar magance wani yanayin, ana iya tsallake lokaci na 1 saboda an riga an nuna maganin ba shi da lafiya. Wannan shi ake kira dawo da magani, kuma shine mahimmin sashi na mu Dabarun bincike na EB.
Drug repurposing ne mai yuwuwar a cikin sauri hanya don kulla m magani jiyya ga mutane tare da kowane irin EB, domin shi ba ya unsa mataki 1. Har ila yau, yana da rahusa saboda an mayar da hankali a kan asibiti gwajin data kasance kwayoyi amfani da nasarar magance alaka yanayi.
Don EB akwai magunguna da aka riga aka samu a cikin NHS waɗanda suka sami nasarar magance wasu yanayin fata masu kumburi, gami da psoriasis da atopic dermatitis (ƙananan eczema), wanda zai iya inganta haɓakar alamun EB kamar blistering da ingancin rayuwa gabaɗaya. Don tabbatar da tasirin waɗannan magungunan don maganin EB ko da yake yana buƙatar gwaji ta hanyar gwaji na asibiti.
Dabarun binciken mu na EB suna ba da fifikon saka hannun jari a cikin sake fasalin ƙwayoyi don amintaccen jiyya masu canza rayuwa ga kowane nau'in EB.
Ta hanyar fahimtar yadda jiyya ke aiki da kuma yadda ake haifar da alamar EB, masu binciken EB na iya gano jiyya tare da yuwuwar sake dawowa.
Kwararrun likitocin na iya ba wa wasu ƴan marasa lafiyar EB damar gwada 'lakabin-lakabin' magani. Wannan yana nufin yana da lasisi don kula da wani yanayi banda EB. Suna nazarin sakamakon a hankali kuma suna buga sakamakon su azaman nazarin yanayin. Koyaya, don mayar da magani, a gwajin gwaji shigar da ƙarin marasa lafiya za su buƙaci gudanar da su don tabbatar da cewa kyakkyawan sakamako da aka gani a cikin binciken farko ba kawai saboda kwatsam ba.
An tabbatar da tsarin sake dawo da kwayoyi don ceton rayuka.
Wataƙila ka yi amfani da magungunan da aka sake amfani da su da kanka. Lokacin da cutar ta COVID-19 ta fara, an yi gaggawar sake dawo da magungunan da za su iya taimakawa. Likitoci sun yi amfani da iliminsu na kwayar cutar wajen zabar magunguna, kuma an fara gwajin asibiti don ganin ko hasashen da suka yi na ilimi daidai ne.
Aspirin misali ne na maganin da aka saba da shi wanda aka yi nasarar sakewa. Daga farkon amfani da shi akan zafi, zazzabi, da kumburi, yanzu ana amfani dashi a cikin ƙananan allurai don rage damar bugun zuciya da bugun jini.
A wasu lokuta, illolin magani yana ba da damar sake dawowa, alal misali, Viagra an fara haɓaka shi don magance angina, amma sakamakon da aka lura da shi ya haifar da sake dawowa don magance tabarbarewa. Har ila yau, an yi nasarar sake yin magunguna daban-daban don magance ciwon daji na nono da suka hada da maganin rigakafi, anti-virus, maganin cututtuka na autoimmune, magungunan wasu cututtuka da magungunan da aka yi amfani da su a asali don taimakawa wajen rashin haihuwa.
Sauran mutanen da ke zaune tare yanayi mai wuya ciki har da tuberous sclerosis, alkaptonuria, da autoimmune lymphoproliferative syndrome sun kuma amfana daga binciken sake amfani da miyagun ƙwayoyi da gwaje-gwaje na asibiti wanda ya haifar da amincewa da magungunan da ake ciki don magance waɗannan yanayi.
Magunguna da yawa suna da ƙarin tasiri waɗanda ke nufin ana iya amfani da su don magance alamun ban da waɗanda aka ba su lasisin asali. Inda sakamako ɗaya shine don rage kumburin fata, kumburi, itching, ko tabo, waɗannan kwayoyi na iya zama masu dacewa musamman ga mutanen da ke da EB.
Podcast: Karkashin Fata
Tare da Chris Griffiths OBE.
A cikin shiri na musamman na Under the Skin wanda Adam Cox ya shirya, Farfesa Chris Griffiths OBE yayi magana game da babban tasirin Epidermolysis Bullosa (EB) akan mutane da iyalai. Ya shiga cikin sabbin ci gaba a cikin jiyya da haɓaka magunguna, yana nuna mahimmancin ci gaba da bincike a fagen. Tattaunawar ta kuma shafi wasu yanayin fata, tana ba da faffadan hangen nesa kan ƙalubalen dermatological. Farfesa Griffiths yana ba da bayanai daga babban aikinsa a fannin ilimin fata, gami da matsayinsa na mai ba da shawara mai zaman kansa ga DEBRA UK, Inda ya goyi bayan ayyukan bincike da nufin rage ciwon da ke hade da EB.